Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles

Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles

Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal cord. The inhibitory effect of polynitroxylated albumin (PNA), a caged nitroxide nanoparticle, on leptomeningeal dissemination and metastatic...

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Bibliographic Details
Main Authors: Bohdan J. Soltys, Katie B. Grausam, Shanta M. Messerli, Carleton J. C. Hsia, Haotian Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
Sonic Hedgehog
medulloblastoma
metastasis
leptomeningeal dissemination
hematogenous dissemination
nitroxide
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1129533/full

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