The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics
Alzheimer’s disease (AD) is one of the main causes of disability and dependency among elderly people. AD is a neurodegenerative disorder characterized by a progressive and irreversible cognitive impairment, whose etiology is unclear because of the complex molecular mechanisms involved in i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/10/4/190 |
| _version_ | 1828349975214424064 |
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| author | Cristina de la Torre Valentín Ceña |
| author_facet | Cristina de la Torre Valentín Ceña |
| author_sort | Cristina de la Torre |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is one of the main causes of disability and dependency among elderly people. AD is a neurodegenerative disorder characterized by a progressive and irreversible cognitive impairment, whose etiology is unclear because of the complex molecular mechanisms involved in its pathophysiology. A global view of the AD pathophysiology is described in order to understand the need for an effective treatment and why nanoparticles (NPs) could be an important weapon against neurodegenerative diseases by solving the general problem of poor delivery into the central nervous system (CNS) for many drugs. Drug delivery into the CNS is one of the most challenging objectives in pharmaceutical design, due to the limited access to the CNS imposed by the blood-brain barrier (BBB). The purpose of this review is to present a comprehensive overview of the use of NPs as delivery systems for therapeutic and diagnostic purposes in models of AD. |
| first_indexed | 2024-04-14T01:18:26Z |
| format | Article |
| id | doaj.art-5d3db47a41114159945d9872aeff44ee |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-14T01:18:26Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-5d3db47a41114159945d9872aeff44ee2022-12-22T02:20:44ZengMDPI AGPharmaceutics1999-49232018-10-0110419010.3390/pharmaceutics10040190pharmaceutics10040190The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and DiagnosticsCristina de la Torre0Valentín Ceña1Unidad Asociada Neurodeath, Universidad de Castilla-La Mancha, Almansa, 14, 02006 Albacete, SpainUnidad Asociada Neurodeath, Universidad de Castilla-La Mancha, Almansa, 14, 02006 Albacete, SpainAlzheimer’s disease (AD) is one of the main causes of disability and dependency among elderly people. AD is a neurodegenerative disorder characterized by a progressive and irreversible cognitive impairment, whose etiology is unclear because of the complex molecular mechanisms involved in its pathophysiology. A global view of the AD pathophysiology is described in order to understand the need for an effective treatment and why nanoparticles (NPs) could be an important weapon against neurodegenerative diseases by solving the general problem of poor delivery into the central nervous system (CNS) for many drugs. Drug delivery into the CNS is one of the most challenging objectives in pharmaceutical design, due to the limited access to the CNS imposed by the blood-brain barrier (BBB). The purpose of this review is to present a comprehensive overview of the use of NPs as delivery systems for therapeutic and diagnostic purposes in models of AD.http://www.mdpi.com/1999-4923/10/4/190Alzheimer’s diseaseblood-brain barriernanoparticlesanimal models |
| spellingShingle | Cristina de la Torre Valentín Ceña The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics Pharmaceutics Alzheimer’s disease blood-brain barrier nanoparticles animal models |
| title | The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics |
| title_full | The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics |
| title_fullStr | The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics |
| title_full_unstemmed | The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics |
| title_short | The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics |
| title_sort | delivery challenge in neurodegenerative disorders the nanoparticles role in alzheimer s disease therapeutics and diagnostics |
| topic | Alzheimer’s disease blood-brain barrier nanoparticles animal models |
| url | http://www.mdpi.com/1999-4923/10/4/190 |
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