Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats
Background : The exposure of free radicals can induce oxidative stress. In the liver, this process will cause impaired liver function. Oxidative stress can be inhibited by antioxidants. Arrowroot tubers (Maranta arundinacea) contains phenolic, flavonoid, alkaloids and saponin compound that are poten...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine
2017-04-01
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| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Subjects: | |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/7971 |
| _version_ | 1818064278786146304 |
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| author | Muhammad Reza Ramadhani Mochammad Saiful Bachri Wahyu Widyaningsih |
| author_facet | Muhammad Reza Ramadhani Mochammad Saiful Bachri Wahyu Widyaningsih |
| author_sort | Muhammad Reza Ramadhani |
| collection | DOAJ |
| description | Background : The exposure of free radicals can induce oxidative stress. In the liver, this process will cause impaired liver function. Oxidative stress can be inhibited by antioxidants. Arrowroot tubers (Maranta arundinacea) contains phenolic, flavonoid, alkaloids and saponin compound that are potential as antioxidants.
Objective : Determine the effect of ethanolic extract of arrowroot tubers (Maranta arundinacea) against oxidative stress using the parameter of MDA, SGPT and SGOT level in ethanol-induced rats.
Methods : Animal models were divided into 5 groups, in which each group contained 6 rats. Group I (normal) and group II (control) was induced with CMC Na 0,5%. Group III, IV and V were given ethanolic extract of arrowroot tubers in the dosage of 125, 250 and 500 mg/Kg/day respectively. The extract was administered orally for 14 days. Induction of ethanol 5 gram/ KgBW was administered orally 1 hour after the last administration on day 14th except for group I. On day 15th, the animal blood was drawn to measure the levels of SGPT and SGOT, then the animals were sacrificed and their organs were analyzed to measure the levels of MDA in the liver. Data obtained in the form of MDA, SGPT and SGOT levels were statistically analyzed using ANOVA.
Results : There is statistically significant difference between the utilization of ethanolic extract of arrowroot tubers (Maranta arundinacea) group with the control group in reducing the concentration of MDA (p<0,05), SGPT, and SGOT (p<0,05).
Conclusions : The ethanolic extract of arrowroot tubers (Maranta arundinacea) is able to reduce the concentration of MDA, SGPT and SGOT in ethanol-induced rats. |
| first_indexed | 2024-12-10T14:33:28Z |
| format | Article |
| id | doaj.art-5d3e64bd212a4bf1b05ac5b6859423ac |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-12-10T14:33:28Z |
| publishDate | 2017-04-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-5d3e64bd212a4bf1b05ac5b6859423ac2022-12-22T01:44:53ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502017-04-0181101810.20885/JKKI.Vol8.Iss1.art36740Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced ratsMuhammad Reza Ramadhani0Mochammad Saiful Bachri1Wahyu Widyaningsih2Magister Faculty of Pharmacy Ahmad Dahlan University, Yogyakarta, IndonesiaFaculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, IndonesiaFaculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, IndonesiaBackground : The exposure of free radicals can induce oxidative stress. In the liver, this process will cause impaired liver function. Oxidative stress can be inhibited by antioxidants. Arrowroot tubers (Maranta arundinacea) contains phenolic, flavonoid, alkaloids and saponin compound that are potential as antioxidants. Objective : Determine the effect of ethanolic extract of arrowroot tubers (Maranta arundinacea) against oxidative stress using the parameter of MDA, SGPT and SGOT level in ethanol-induced rats. Methods : Animal models were divided into 5 groups, in which each group contained 6 rats. Group I (normal) and group II (control) was induced with CMC Na 0,5%. Group III, IV and V were given ethanolic extract of arrowroot tubers in the dosage of 125, 250 and 500 mg/Kg/day respectively. The extract was administered orally for 14 days. Induction of ethanol 5 gram/ KgBW was administered orally 1 hour after the last administration on day 14th except for group I. On day 15th, the animal blood was drawn to measure the levels of SGPT and SGOT, then the animals were sacrificed and their organs were analyzed to measure the levels of MDA in the liver. Data obtained in the form of MDA, SGPT and SGOT levels were statistically analyzed using ANOVA. Results : There is statistically significant difference between the utilization of ethanolic extract of arrowroot tubers (Maranta arundinacea) group with the control group in reducing the concentration of MDA (p<0,05), SGPT, and SGOT (p<0,05). Conclusions : The ethanolic extract of arrowroot tubers (Maranta arundinacea) is able to reduce the concentration of MDA, SGPT and SGOT in ethanol-induced rats.https://journal.uii.ac.id/JKKI/article/view/7971Maranta arundinacea, antioxidant, MDA, SGPT, SGOT |
| spellingShingle | Muhammad Reza Ramadhani Mochammad Saiful Bachri Wahyu Widyaningsih Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) Maranta arundinacea, antioxidant, MDA, SGPT, SGOT |
| title | Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats |
| title_full | Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats |
| title_fullStr | Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats |
| title_full_unstemmed | Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats |
| title_short | Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats |
| title_sort | effects of ethanolic extract of arrowroot tubers maranta arundinacea l on the level of mda sgpt and sgot in ethanol induced rats |
| topic | Maranta arundinacea, antioxidant, MDA, SGPT, SGOT |
| url | https://journal.uii.ac.id/JKKI/article/view/7971 |
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