From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy
Traditional cancer therapy methods, especially those directed against specific intracellular targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity and therapeutic resistance. Oncolytic peptides that can induce membrane lysis-mediated cancer cell death and subsequent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23002475 |
| _version_ | 1827267083715477504 |
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| author | Hanmeng Liu Wei Shen Wanguo Liu Zexin Yang Dengke Yin Chunsheng Xiao |
| author_facet | Hanmeng Liu Wei Shen Wanguo Liu Zexin Yang Dengke Yin Chunsheng Xiao |
| author_sort | Hanmeng Liu |
| collection | DOAJ |
| description | Traditional cancer therapy methods, especially those directed against specific intracellular targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity and therapeutic resistance. Oncolytic peptides that can induce membrane lysis-mediated cancer cell death and subsequent anticancer immune responses, has provided a new paradigm for cancer therapy. However, the clinical application of oncolytic peptides is always limited by some factors such as unsatisfactory bio-distribution, poor stability, and off-target toxicity. To overcome these limitations, oncolytic polymers stand out as prospective therapeutic materials owing to their high stability, chemical versatility, and scalable production capacity, which has the potential to drive a revolution in cancer treatment. This review provides an overview of the mechanism and structure-activity relationship of oncolytic peptides. Then the oncolytic peptides-mediated combination therapy and the nano-delivery strategies for oncolytic peptides are summarized. Emphatically, the current research progress of oncolytic polymers has been highlighted. Lastly, the challenges and prospects in the development of oncolytic polymers are discussed. |
| first_indexed | 2024-03-12T14:42:57Z |
| format | Article |
| id | doaj.art-5d40660f9d3a495ab3ca68100c0eeb51 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2025-03-22T04:28:06Z |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-5d40660f9d3a495ab3ca68100c0eeb512024-04-28T04:55:06ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2024-01-0131206230From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapyHanmeng Liu0Wei Shen1Wanguo Liu2Zexin Yang3Dengke Yin4Chunsheng Xiao5School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, Anhui, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, Anhui, 230012, China; Corresponding author. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.Department of Orthopaedic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, Anhui, 230012, China; Corresponding author. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Corresponding author. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.Traditional cancer therapy methods, especially those directed against specific intracellular targets or signaling pathways, are not powerful enough to overcome tumor heterogeneity and therapeutic resistance. Oncolytic peptides that can induce membrane lysis-mediated cancer cell death and subsequent anticancer immune responses, has provided a new paradigm for cancer therapy. However, the clinical application of oncolytic peptides is always limited by some factors such as unsatisfactory bio-distribution, poor stability, and off-target toxicity. To overcome these limitations, oncolytic polymers stand out as prospective therapeutic materials owing to their high stability, chemical versatility, and scalable production capacity, which has the potential to drive a revolution in cancer treatment. This review provides an overview of the mechanism and structure-activity relationship of oncolytic peptides. Then the oncolytic peptides-mediated combination therapy and the nano-delivery strategies for oncolytic peptides are summarized. Emphatically, the current research progress of oncolytic polymers has been highlighted. Lastly, the challenges and prospects in the development of oncolytic polymers are discussed.http://www.sciencedirect.com/science/article/pii/S2452199X23002475Oncolytic polymersOncolytic peptidesCancer therapyTherapeutic resistanceImmunotherapy |
| spellingShingle | Hanmeng Liu Wei Shen Wanguo Liu Zexin Yang Dengke Yin Chunsheng Xiao From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy Bioactive Materials Oncolytic polymers Oncolytic peptides Cancer therapy Therapeutic resistance Immunotherapy |
| title | From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy |
| title_full | From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy |
| title_fullStr | From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy |
| title_full_unstemmed | From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy |
| title_short | From oncolytic peptides to oncolytic polymers: A new paradigm for oncotherapy |
| title_sort | from oncolytic peptides to oncolytic polymers a new paradigm for oncotherapy |
| topic | Oncolytic polymers Oncolytic peptides Cancer therapy Therapeutic resistance Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23002475 |
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