Obesity: genetics and immunopathogenesis
Background: variability of body weight in obese or overweight individuals can be attributed to genetic factors. There is a genetic classification of obesity according to these factors and in all of them there is evidence of a complex interaction between cells of the innate and adaptive immune system...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Ciencias Médicas de Las Tunas
2023-06-01
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| Series: | Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta |
| Subjects: | |
| Online Access: | https://revzoilomarinello.sld.cu/index.php/zmv/article/view/3338 |
| _version_ | 1797384607696420864 |
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| author | Enelis Reyes-Reyes Carmen Rosa Rodríguez-Valenciano Lisset del Carmen Romero-Portelles |
| author_facet | Enelis Reyes-Reyes Carmen Rosa Rodríguez-Valenciano Lisset del Carmen Romero-Portelles |
| author_sort | Enelis Reyes-Reyes |
| collection | DOAJ |
| description | Background: variability of body weight in obese or overweight individuals can be attributed to genetic factors. There is a genetic classification of obesity according to these factors and in all of them there is evidence of a complex interaction between cells of the innate and adaptive immune system, with imbalances and alterations in homeostasis and control of inflammation of adipose tissue.
Objective: to deepen into the genetic origin and immunopathogenesis of obesity, according to the updated scientific literature.
Methods: a bibliographic review was carried out, in English and Spanish, through PubMed website and Google Scholar. The keywords used were: obesity, genetic factors, immune system, immunopathogenesis.
Results: monogenic, syndromic and polygenic obesities, genes and genetic factors, the interaction between genetics and epigenetics, environment and microenvironment, as well as the main immunological pathogenic mechanisms involved are detailed. Obesity is predominantly of multifactorial origin, where genetic factors are essential components in genesis. In its pathogenesis, it involves an immune imbalance to proinflammatory predominance, which results in a chronic and progressive inflammatory disease.
Conclusions: a review article was published with contents on the genetic origin and immunopathogenesis of obesity. |
| first_indexed | 2024-03-08T21:38:06Z |
| format | Article |
| id | doaj.art-5d40c3ba2af14ce8807a586feccceb5b |
| institution | Directory Open Access Journal |
| issn | 1029-3027 |
| language | Spanish |
| last_indexed | 2024-03-08T21:38:06Z |
| publishDate | 2023-06-01 |
| publisher | Universidad de Ciencias Médicas de Las Tunas |
| record_format | Article |
| series | Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta |
| spelling | doaj.art-5d40c3ba2af14ce8807a586feccceb5b2023-12-20T16:54:48ZspaUniversidad de Ciencias Médicas de Las TunasRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta1029-30272023-06-01480e3338e33381330Obesity: genetics and immunopathogenesisEnelis Reyes-Reyes0Carmen Rosa Rodríguez-Valenciano1Lisset del Carmen Romero-Portelles2Hospital Pediátrico Provincial “Mártires de Las Tunas”. Departamento Provincial de Genética Médica. Universidad de Ciencias Médicas de Las Tunas. Las Tunas.Hospital Pediátrico Provincial “Mártires de Las Tunas”. Departamento Provincial de Genética Médica. Universidad de Ciencias Médicas de Las Tunas. Las Tunas.Hospital Pediátrico Provincial “Mártires de Las Tunas”. Departamento Provincial de Genética Médica. Universidad de Ciencias Médicas de Las Tunas. Las Tunas.Background: variability of body weight in obese or overweight individuals can be attributed to genetic factors. There is a genetic classification of obesity according to these factors and in all of them there is evidence of a complex interaction between cells of the innate and adaptive immune system, with imbalances and alterations in homeostasis and control of inflammation of adipose tissue. Objective: to deepen into the genetic origin and immunopathogenesis of obesity, according to the updated scientific literature. Methods: a bibliographic review was carried out, in English and Spanish, through PubMed website and Google Scholar. The keywords used were: obesity, genetic factors, immune system, immunopathogenesis. Results: monogenic, syndromic and polygenic obesities, genes and genetic factors, the interaction between genetics and epigenetics, environment and microenvironment, as well as the main immunological pathogenic mechanisms involved are detailed. Obesity is predominantly of multifactorial origin, where genetic factors are essential components in genesis. In its pathogenesis, it involves an immune imbalance to proinflammatory predominance, which results in a chronic and progressive inflammatory disease. Conclusions: a review article was published with contents on the genetic origin and immunopathogenesis of obesity.https://revzoilomarinello.sld.cu/index.php/zmv/article/view/3338obesidadgenética médicasistema inmunológico |
| spellingShingle | Enelis Reyes-Reyes Carmen Rosa Rodríguez-Valenciano Lisset del Carmen Romero-Portelles Obesity: genetics and immunopathogenesis Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta obesidad genética médica sistema inmunológico |
| title | Obesity: genetics and immunopathogenesis |
| title_full | Obesity: genetics and immunopathogenesis |
| title_fullStr | Obesity: genetics and immunopathogenesis |
| title_full_unstemmed | Obesity: genetics and immunopathogenesis |
| title_short | Obesity: genetics and immunopathogenesis |
| title_sort | obesity genetics and immunopathogenesis |
| topic | obesidad genética médica sistema inmunológico |
| url | https://revzoilomarinello.sld.cu/index.php/zmv/article/view/3338 |
| work_keys_str_mv | AT enelisreyesreyes obesitygeneticsandimmunopathogenesis AT carmenrosarodriguezvalenciano obesitygeneticsandimmunopathogenesis AT lissetdelcarmenromeroportelles obesitygeneticsandimmunopathogenesis |