New mechanistic insights into the RAS-SIN1 interaction at the membrane

New mechanistic insights into the RAS-SIN1 interaction at the membrane

Stress-activated MAP kinase-interacting protein 1 (SIN1) is a central member of the mTORC2 complex that contains an N-terminal domain (NTD), a conserved region in the middle (CRIM), a RAS-binding domain (RBD), and a pleckstrin homology domain. Recent studies provided valuable structural and function...

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Bibliographic Details
Main Authors: Silke Pudewell, Jana Lissy, Hossein Nakhaeizadeh, Niloufar Mosaddeghzadeh, Saeideh Nakhaei-Rad, Radovan Dvorsky, Mohammad R. Ahmadian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RAS
RAS family
SIN1
MAPKAP1
mTORC2
ras binding domain
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.987754/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.987754/full

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