Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia
Background Despite various strategies designed for preventing pain from propofol injection, it is still common and distressing to the patients. The purpose of the present study was to investigate the adequate effect-site concentration (Ce) of remifentanil to prevent pain due to propofol injection. M...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2020-04-01
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| Series: | Anesthesia and Pain Medicine |
| Subjects: | |
| Online Access: | http://www.anesth-pain-med.org/upload/pdf/apm-2020-15-2-152.pdf |
| _version_ | 1797825455866249216 |
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| author | Joungmin Kim Daehoon Kim Hyung Gong Lee |
| author_facet | Joungmin Kim Daehoon Kim Hyung Gong Lee |
| author_sort | Joungmin Kim |
| collection | DOAJ |
| description | Background Despite various strategies designed for preventing pain from propofol injection, it is still common and distressing to the patients. The purpose of the present study was to investigate the adequate effect-site concentration (Ce) of remifentanil to prevent pain due to propofol injection. Methods A total of 160 adults scheduled for elective surgery were randomly assigned to one of four groups receiving normal saline (group S) or remifentanil at a Ce of 2 (group R2), 3 (group R3), or 4 ng/ml (group R4), administered via target-controlled infusion, followed by the injection of 2 mg/kg of propofol (delivered with 1% lipid propofol). The severity and incidence of injection pain were assessed on a four-point scale. Results The incidence of propofol injection pain was significantly lower in group R2, R3, or R4 than in group S (30%, 5%, or 2.5% vs. 70%, respectively). Moreover, the intensity of the pain was lesser in group R2, R3, or R4 than in group S. However, the incidence or severity of injection was not different between groups R3 and R4. Conclusions During the induction of balanced anesthesia using propofol injection, pretreatment with remifentanil at a target Ce of 3 ng/ml effectively reduced propofol injection pain in adults. |
| first_indexed | 2024-03-13T10:54:17Z |
| format | Article |
| id | doaj.art-5d41545b3b3b4388b4997cb4d505f408 |
| institution | Directory Open Access Journal |
| issn | 1975-5171 2383-7977 |
| language | English |
| last_indexed | 2024-03-13T10:54:17Z |
| publishDate | 2020-04-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Anesthesia and Pain Medicine |
| spelling | doaj.art-5d41545b3b3b4388b4997cb4d505f4082023-05-17T05:33:43ZengKorean Society of AnesthesiologistsAnesthesia and Pain Medicine1975-51712383-79772020-04-0115215215610.17085/apm.2020.15.2.1521005Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesiaJoungmin Kim0Daehoon Kim1Hyung Gong Lee2 Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea Department of Anesthesiology and Pain Medicine ,Chonnam National University Hospital, Gwangju, Korea Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, KoreaBackground Despite various strategies designed for preventing pain from propofol injection, it is still common and distressing to the patients. The purpose of the present study was to investigate the adequate effect-site concentration (Ce) of remifentanil to prevent pain due to propofol injection. Methods A total of 160 adults scheduled for elective surgery were randomly assigned to one of four groups receiving normal saline (group S) or remifentanil at a Ce of 2 (group R2), 3 (group R3), or 4 ng/ml (group R4), administered via target-controlled infusion, followed by the injection of 2 mg/kg of propofol (delivered with 1% lipid propofol). The severity and incidence of injection pain were assessed on a four-point scale. Results The incidence of propofol injection pain was significantly lower in group R2, R3, or R4 than in group S (30%, 5%, or 2.5% vs. 70%, respectively). Moreover, the intensity of the pain was lesser in group R2, R3, or R4 than in group S. However, the incidence or severity of injection was not different between groups R3 and R4. Conclusions During the induction of balanced anesthesia using propofol injection, pretreatment with remifentanil at a target Ce of 3 ng/ml effectively reduced propofol injection pain in adults.http://www.anesth-pain-med.org/upload/pdf/apm-2020-15-2-152.pdfinjectionpainpropofolremifentaniltarget-controlled infusion |
| spellingShingle | Joungmin Kim Daehoon Kim Hyung Gong Lee Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia Anesthesia and Pain Medicine injection pain propofol remifentanil target-controlled infusion |
| title | Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia |
| title_full | Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia |
| title_fullStr | Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia |
| title_full_unstemmed | Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia |
| title_short | Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia |
| title_sort | effect site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia |
| topic | injection pain propofol remifentanil target-controlled infusion |
| url | http://www.anesth-pain-med.org/upload/pdf/apm-2020-15-2-152.pdf |
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