Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor

Pharmacophore Selection and Redesign of Non-nucleotide Inhibitors of Anthrax Edema Factor

Antibiotic treatment may fail to protect individuals, if not started early enough, after infection with Bacillus anthracis, due to the continuing activity of toxins that the bacterium produces. Stable and easily stored inhibitors of the edema factor toxin (EF), an adenylyl cyclase, could save lives...

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Bibliographic Details
Main Authors: Maria Estrella Jimenez, Laurie E. Sower, Mary A. Walter, Scott R. Gilbertson, Johnny W. Peterson, John J. Kanalas, Jian Gao, Lili Ma, Deliang Chen, Catherine H. Schein
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Toxins
Subjects:
computational design
library screening
fluorenone
adenylyl cyclase toxin
Online Access:http://www.mdpi.com/2072-6651/4/11/1288

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