Human B Cells Engage the NCK/PI3K/RAC1 Axis to Internalize Large Particles via the IgM-BCR

Human B Cells Engage the NCK/PI3K/RAC1 Axis to Internalize Large Particles via the IgM-BCR

Growing evidence indicate that large antigen-containing particles induce potent T cell-dependent high-affinity antibody responses. These responses require large particle internalization after recognition by the B cell receptor (BCR) on B cells. However, the molecular mechanisms governing BCR-mediate...

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Bibliographic Details
Main Authors: Niels J. M. Verstegen, Peter-Paul A. Unger, Julia Z. Walker, Benoit P. Nicolet, Tineke Jorritsma, Jos van Rijssel, Robbert M. Spaapen, Jelle de Wit, Jaap D. van Buul, Anja ten Brinke, S. Marieke van Ham
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
B cell
CRISPR
internalization
signaling pathway
large antigen-containing particle
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00415/full

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