LC3-associated phagocytosis promotes glial degradation of axon debris after injury in Drosophila models
Abstract Glial engulfment of neuron-derived debris after trauma, during development, and in neurodegenerative diseases supports nervous system functions. However, mechanisms governing the efficiency of debris degradation in glia have remained largely unexplored. Here we show that LC3-associated phag...
Main Authors: | Áron Szabó, Virág Vincze, Aishwarya Sanjay Chhatre, András Jipa, Sarolta Bognár, Katalin Eszter Varga, Poulami Banik, Adél Harmatos-Ürmösi, Lukas J. Neukomm, Gábor Juhász |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-05-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-38755-4 |
Similar Items
-
Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis.
by: Kelsey A Herrmann, et al.
Published: (2022-06-01) -
Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
by: Tsai-Yi Lu, et al.
Published: (2017-02-01) -
Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
by: Johannes Westman, et al.
Published: (2020-01-01) -
CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils
by: Elias Haj-Yehia, et al.
Published: (2023-10-01) -
Stressed axons craving for glial sugar: links to regeneration?
by: Elisabetta Babetto, et al.
Published: (2022-01-01)