Mitochondria Transfer in Brain Injury and Disease
Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between gl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/22/3603 |
| _version_ | 1797465638415892480 |
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| author | Lauren H. Fairley Amandine Grimm Anne Eckert |
| author_facet | Lauren H. Fairley Amandine Grimm Anne Eckert |
| author_sort | Lauren H. Fairley |
| collection | DOAJ |
| description | Intercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between glia and neurons in the brain, and mitochondrial transfer has emerged as a key neuroprotective mechanism in a range of neurological conditions. In particular, artificial mitochondria transfer has sparked widespread interest as a potential therapeutic strategy for brain disorders. In this review, we discuss the mechanisms and effects of intercellular mitochondria transfer in the brain. The role of mitochondrial transfer in neurological conditions, including neurodegenerative disease, brain injury, and neurodevelopmental disorders, is discussed as well as therapeutic strategies targeting mitochondria transfer in the brain. |
| first_indexed | 2024-03-09T18:25:20Z |
| format | Article |
| id | doaj.art-5d46a0e2d5c54b1683124bdd69dd3804 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T18:25:20Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5d46a0e2d5c54b1683124bdd69dd38042023-11-24T07:58:04ZengMDPI AGCells2073-44092022-11-011122360310.3390/cells11223603Mitochondria Transfer in Brain Injury and DiseaseLauren H. Fairley0Amandine Grimm1Anne Eckert2Transfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, 4002 Basel, SwitzerlandTransfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, 4002 Basel, SwitzerlandTransfaculty Research Platform Molecular and Cognitive Neuroscience, University of Basel, 4002 Basel, SwitzerlandIntercellular mitochondria transfer is a novel form of cell signalling in which whole mitochondria are transferred between cells in order to enhance cellular functions or aid in the degradation of dysfunctional mitochondria. Recent studies have observed intercellular mitochondria transfer between glia and neurons in the brain, and mitochondrial transfer has emerged as a key neuroprotective mechanism in a range of neurological conditions. In particular, artificial mitochondria transfer has sparked widespread interest as a potential therapeutic strategy for brain disorders. In this review, we discuss the mechanisms and effects of intercellular mitochondria transfer in the brain. The role of mitochondrial transfer in neurological conditions, including neurodegenerative disease, brain injury, and neurodevelopmental disorders, is discussed as well as therapeutic strategies targeting mitochondria transfer in the brain.https://www.mdpi.com/2073-4409/11/22/3603mitochondriabrainneuronglia |
| spellingShingle | Lauren H. Fairley Amandine Grimm Anne Eckert Mitochondria Transfer in Brain Injury and Disease Cells mitochondria brain neuron glia |
| title | Mitochondria Transfer in Brain Injury and Disease |
| title_full | Mitochondria Transfer in Brain Injury and Disease |
| title_fullStr | Mitochondria Transfer in Brain Injury and Disease |
| title_full_unstemmed | Mitochondria Transfer in Brain Injury and Disease |
| title_short | Mitochondria Transfer in Brain Injury and Disease |
| title_sort | mitochondria transfer in brain injury and disease |
| topic | mitochondria brain neuron glia |
| url | https://www.mdpi.com/2073-4409/11/22/3603 |
| work_keys_str_mv | AT laurenhfairley mitochondriatransferinbraininjuryanddisease AT amandinegrimm mitochondriatransferinbraininjuryanddisease AT anneeckert mitochondriatransferinbraininjuryanddisease |