Interrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes

Interrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes

Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics that are controlled by Rho GTPases. SRF is a ubiquitous transcription factor strongly expressed in muscular tissues. The depletion of SRF in the adult mouse heart leads...

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Bibliographic Details
Main Authors: Mark-Alexander Gorey, Mathias Mericskay, Zhenlin Li, Jean-François Decaux
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
MRTFA
nucleocytoplasmic shuttle
α-cardiac actin
SRF
RhoA/ROCK signaling pathway
polymerization
Online Access:https://www.mdpi.com/1422-0067/23/13/7394

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