EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment
Cancer research has prioritized the study of the tumor microenvironment (TME) as a crucial area of investigation. Understanding the communication between tumor cells and the various cell types within the TME has become a focal point. Bidirectional communication processes between these cells support...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13085 |
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| author | Francisca Sepúlveda Cristina Mayorga-Lobos Kevin Guzmán Eduardo Durán-Jara Lorena Lobos-González |
| author_facet | Francisca Sepúlveda Cristina Mayorga-Lobos Kevin Guzmán Eduardo Durán-Jara Lorena Lobos-González |
| author_sort | Francisca Sepúlveda |
| collection | DOAJ |
| description | Cancer research has prioritized the study of the tumor microenvironment (TME) as a crucial area of investigation. Understanding the communication between tumor cells and the various cell types within the TME has become a focal point. Bidirectional communication processes between these cells support cellular transformation, as well as the survival, invasion, and metastatic dissemination of tumor cells. Extracellular vesicles are lipid bilayer structures secreted by cells that emerge as important mediators of this cell-to-cell communication. EVs transfer their molecular cargo, including proteins and nucleic acids, and particularly microRNAs, which play critical roles in intercellular communication. Tumor-derived EVs, for example, can promote angiogenesis and enhance endothelial permeability by delivering specific miRNAs. Moreover, adipocytes, a significant component of the breast stroma, exhibit high EV secretory activity, which can then modulate metabolic processes, promoting the growth, proliferation, and migration of tumor cells. Comprehensive studies investigating the involvement of EVs and their miRNA cargo in the TME, as well as their underlying mechanisms driving tumoral capacities, are necessary for a deeper understanding of these complex interactions. Such knowledge holds promise for the development of novel diagnostic and therapeutic strategies in cancer treatment. |
| first_indexed | 2024-03-10T23:22:32Z |
| format | Article |
| id | doaj.art-5d4893f02c1a45898723683a9710fed9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:22:32Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5d4893f02c1a45898723683a9710fed92023-11-19T08:12:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124171308510.3390/ijms241713085EV-miRNA-Mediated Intercellular Communication in the Breast Tumor MicroenvironmentFrancisca Sepúlveda0Cristina Mayorga-Lobos1Kevin Guzmán2Eduardo Durán-Jara3Lorena Lobos-González4Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610615, ChileCentro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610615, ChileCentro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610615, ChileSubdepartamento de Genética Molecular, Instituto de Salud Pública de Chile, Santiago 7780050, ChileCentro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610615, ChileCancer research has prioritized the study of the tumor microenvironment (TME) as a crucial area of investigation. Understanding the communication between tumor cells and the various cell types within the TME has become a focal point. Bidirectional communication processes between these cells support cellular transformation, as well as the survival, invasion, and metastatic dissemination of tumor cells. Extracellular vesicles are lipid bilayer structures secreted by cells that emerge as important mediators of this cell-to-cell communication. EVs transfer their molecular cargo, including proteins and nucleic acids, and particularly microRNAs, which play critical roles in intercellular communication. Tumor-derived EVs, for example, can promote angiogenesis and enhance endothelial permeability by delivering specific miRNAs. Moreover, adipocytes, a significant component of the breast stroma, exhibit high EV secretory activity, which can then modulate metabolic processes, promoting the growth, proliferation, and migration of tumor cells. Comprehensive studies investigating the involvement of EVs and their miRNA cargo in the TME, as well as their underlying mechanisms driving tumoral capacities, are necessary for a deeper understanding of these complex interactions. Such knowledge holds promise for the development of novel diagnostic and therapeutic strategies in cancer treatment.https://www.mdpi.com/1422-0067/24/17/13085extracellular vesiclessmall EVscancer progressionmiRNAstumor progressionmetastasis |
| spellingShingle | Francisca Sepúlveda Cristina Mayorga-Lobos Kevin Guzmán Eduardo Durán-Jara Lorena Lobos-González EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment International Journal of Molecular Sciences extracellular vesicles small EVs cancer progression miRNAs tumor progression metastasis |
| title | EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment |
| title_full | EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment |
| title_fullStr | EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment |
| title_full_unstemmed | EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment |
| title_short | EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment |
| title_sort | ev mirna mediated intercellular communication in the breast tumor microenvironment |
| topic | extracellular vesicles small EVs cancer progression miRNAs tumor progression metastasis |
| url | https://www.mdpi.com/1422-0067/24/17/13085 |
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