Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

ABSTRACT Voltage-gated sodium (Nav) channels are essential for the rapid upstroke of action potentials and the propagation of electrical signals in nerves and muscles. Defects of Nav channels are associated with a variety of channelopathies. More than 1000 disease-related mutations have been identif...

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Bibliographic Details
Main Authors: Weiyun Huang, Minhao Liu, S. Frank Yan, Nieng Yan
Format: Article
Language:English
Published: Oxford University Press 2017-02-01
Series:Protein & Cell
Subjects:
Nav channels
channelopathy
Nav1.7
structure modeling
pain
Online Access:http://link.springer.com/article/10.1007/s13238-017-0372-z

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