Are BPA Substitutes as Obesogenic as BPA?
Metabolic diseases, such as obesity, Type II diabetes and hepatic steatosis, are a significant public health concern affecting more than half a billion people worldwide. The prevalence of these diseases is constantly increasing in developed countries, affecting all age groups. The pathogenesis of me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4238 |
| _version_ | 1797434559090917376 |
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| author | Fabiana Oliviero Alice Marmugi Catherine Viguié Véronique Gayrard Nicole Picard-Hagen Laila Mselli-Lakhal |
| author_facet | Fabiana Oliviero Alice Marmugi Catherine Viguié Véronique Gayrard Nicole Picard-Hagen Laila Mselli-Lakhal |
| author_sort | Fabiana Oliviero |
| collection | DOAJ |
| description | Metabolic diseases, such as obesity, Type II diabetes and hepatic steatosis, are a significant public health concern affecting more than half a billion people worldwide. The prevalence of these diseases is constantly increasing in developed countries, affecting all age groups. The pathogenesis of metabolic diseases is complex and multifactorial. Inducer factors can either be genetic or linked to a sedentary lifestyle and/or consumption of high-fat and sugar diets. In 2002, a new concept of “environmental obesogens” emerged, suggesting that environmental chemicals could play an active role in the etiology of obesity. Bisphenol A (BPA), a xenoestrogen widely used in the plastic food packaging industry has been shown to affect many physiological functions and has been linked to reproductive, endocrine and metabolic disorders and cancer. Therefore, the widespread use of BPA during the last 30 years could have contributed to the increased incidence of metabolic diseases. BPA was banned in baby bottles in Canada in 2008 and in all food-oriented packaging in France from 1 January 2015. Since the BPA ban, substitutes with a similar structure and properties have been used by industrials even though their toxic potential is unknown. Bisphenol S has mainly replaced BPA in consumer products as reflected by the almost ubiquitous human exposure to this contaminant. This review focuses on the metabolic effects and targets of BPA and recent data, which suggest comparable effects of the structural analogs used as substitutes. |
| first_indexed | 2024-03-09T10:34:03Z |
| format | Article |
| id | doaj.art-5d4a986479304653941524daa9c1a285 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:34:03Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5d4a986479304653941524daa9c1a2852023-12-01T21:03:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238423810.3390/ijms23084238Are BPA Substitutes as Obesogenic as BPA?Fabiana Oliviero0Alice Marmugi1Catherine Viguié2Véronique Gayrard3Nicole Picard-Hagen4Laila Mselli-Lakhal5ToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, FranceToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, FranceToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, FranceToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, FranceToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, FranceToxAlim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, FranceMetabolic diseases, such as obesity, Type II diabetes and hepatic steatosis, are a significant public health concern affecting more than half a billion people worldwide. The prevalence of these diseases is constantly increasing in developed countries, affecting all age groups. The pathogenesis of metabolic diseases is complex and multifactorial. Inducer factors can either be genetic or linked to a sedentary lifestyle and/or consumption of high-fat and sugar diets. In 2002, a new concept of “environmental obesogens” emerged, suggesting that environmental chemicals could play an active role in the etiology of obesity. Bisphenol A (BPA), a xenoestrogen widely used in the plastic food packaging industry has been shown to affect many physiological functions and has been linked to reproductive, endocrine and metabolic disorders and cancer. Therefore, the widespread use of BPA during the last 30 years could have contributed to the increased incidence of metabolic diseases. BPA was banned in baby bottles in Canada in 2008 and in all food-oriented packaging in France from 1 January 2015. Since the BPA ban, substitutes with a similar structure and properties have been used by industrials even though their toxic potential is unknown. Bisphenol S has mainly replaced BPA in consumer products as reflected by the almost ubiquitous human exposure to this contaminant. This review focuses on the metabolic effects and targets of BPA and recent data, which suggest comparable effects of the structural analogs used as substitutes.https://www.mdpi.com/1422-0067/23/8/4238BPA substitutesmetabolic disordersendocrine disruptors |
| spellingShingle | Fabiana Oliviero Alice Marmugi Catherine Viguié Véronique Gayrard Nicole Picard-Hagen Laila Mselli-Lakhal Are BPA Substitutes as Obesogenic as BPA? International Journal of Molecular Sciences BPA substitutes metabolic disorders endocrine disruptors |
| title | Are BPA Substitutes as Obesogenic as BPA? |
| title_full | Are BPA Substitutes as Obesogenic as BPA? |
| title_fullStr | Are BPA Substitutes as Obesogenic as BPA? |
| title_full_unstemmed | Are BPA Substitutes as Obesogenic as BPA? |
| title_short | Are BPA Substitutes as Obesogenic as BPA? |
| title_sort | are bpa substitutes as obesogenic as bpa |
| topic | BPA substitutes metabolic disorders endocrine disruptors |
| url | https://www.mdpi.com/1422-0067/23/8/4238 |
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