Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study
(1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory reactions activation and may pl...
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/37 |
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| author | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Bartłomiej Perek Marek Jemielity |
| author_facet | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Bartłomiej Perek Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | (1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory reactions activation and may play a clinical role as a predictive marker in oncological and cardiovascular diseases. The aim of the study was to find simple hematologic indices available from whole blood count to help in immunosuppressive therapy monitoring. (2) Methods: Thirty patients (23 men and 7 women) with a mean age of 43 +/− 13 years who had undergone orthotopic heart transplantation were enrolled into the study. The blood samples for whole blood count and Tacrolimus level were collected during outpatient visits in heart transplant recipients every two months for 18 months after first year post transplantation. (3) Results: There was a significant correlation between Tacrolimus overdose (>15 ng/mL) and NLR (Spearman’s rho 0.99, <i>p</i> < 0.001) and mean platelet volume (Spearman’s rho 0.989, <i>p</i> < 0.001). The ROC analysis for NLR above 3.62 showed predictive properties for Tacrolimus overdose (over 15 ng/mL) (AUC =0.633, <i>p</i> = 0.008) with a sensitivity of 50% and specificity of 83.73%. (4) Conclusions: Our results suggest that NLR above 3.62 may be regarded as a simple indicator of tacrolimus overdose. |
| first_indexed | 2024-03-10T01:39:21Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:39:21Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5d4ccec2613f49bbabe0601f9588f53e2023-11-23T13:27:09ZengMDPI AGDiagnostics2075-44182021-12-011213710.3390/diagnostics12010037Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental StudyTomasz Urbanowicz0Anna Olasińska-Wiśniewska1Michał Michalak2Michał Rodzki3Anna Witkowska4Ewa Straburzyńska-Migaj5Bartłomiej Perek6Marek Jemielity7Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland(1) Background: The combination of candidate selection, immunosuppressive therapy adjustment, and scrutinous monitoring is a cornerstone for optimizing long-term survival after a heart transplant. Neutrophil-to-lymphocyte ratio (NLR) is a simple marker of inflammatory reactions activation and may play a clinical role as a predictive marker in oncological and cardiovascular diseases. The aim of the study was to find simple hematologic indices available from whole blood count to help in immunosuppressive therapy monitoring. (2) Methods: Thirty patients (23 men and 7 women) with a mean age of 43 +/− 13 years who had undergone orthotopic heart transplantation were enrolled into the study. The blood samples for whole blood count and Tacrolimus level were collected during outpatient visits in heart transplant recipients every two months for 18 months after first year post transplantation. (3) Results: There was a significant correlation between Tacrolimus overdose (>15 ng/mL) and NLR (Spearman’s rho 0.99, <i>p</i> < 0.001) and mean platelet volume (Spearman’s rho 0.989, <i>p</i> < 0.001). The ROC analysis for NLR above 3.62 showed predictive properties for Tacrolimus overdose (over 15 ng/mL) (AUC =0.633, <i>p</i> = 0.008) with a sensitivity of 50% and specificity of 83.73%. (4) Conclusions: Our results suggest that NLR above 3.62 may be regarded as a simple indicator of tacrolimus overdose.https://www.mdpi.com/2075-4418/12/1/37heart transplantationtacrolimusNLRMPVdrug overdose |
| spellingShingle | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Bartłomiej Perek Marek Jemielity Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study Diagnostics heart transplantation tacrolimus NLR MPV drug overdose |
| title | Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study |
| title_full | Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study |
| title_fullStr | Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study |
| title_full_unstemmed | Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study |
| title_short | Neutrophil to Lymphocyte Ratio (NLR) as an Easily Accessible Parameter for Monitoring Tacrolimus Overdose after Heart Transplantation—Experimental Study |
| title_sort | neutrophil to lymphocyte ratio nlr as an easily accessible parameter for monitoring tacrolimus overdose after heart transplantation experimental study |
| topic | heart transplantation tacrolimus NLR MPV drug overdose |
| url | https://www.mdpi.com/2075-4418/12/1/37 |
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