Evaluation of Anticancer and Anti-Inflammatory Activities of Some Synthetic Rearranged Abietanes

Evaluation of Anticancer and Anti-Inflammatory Activities of Some Synthetic Rearranged Abietanes

Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected orthoquinonic compounds <b>5</b>, <b>7</b>, <b>13</...

Full description

Bibliographic Details
Main Authors:	Mustapha Ait El Had, Houda Zentar, Blanca Ruiz-Muñoz, Juan Sainz, Juan J. Guardia, Antonio Fernández, José Justicia, Enrique Alvarez-Manzaneda, Fernando J. Reyes-Zurita, Rachid Chahboun
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	International Journal of Molecular Sciences
Subjects:	rearranged abietane type semisynthesis antitumor activity apoptosis colorectal cancer anti-inflammatory activity
Online Access:	https://www.mdpi.com/1422-0067/24/17/13583

Similar Items

Synthesis and Evaluation of Antimicrobial Activity of the Rearranged Abietane Prattinin A and Its Synthetic Derivatives
by: Mustapha Ait El Had, et al.
Published: (2024-01-01)

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds
by: Houda Zentar, et al.
Published: (2022-09-01)

Abietane Diterpernoids from the Roots of Euphorbia ebracteolata
by: Yuan-Liang Ma, et al.
Published: (2018-03-01)

Cyclohexylethanoid derivative and rearranged abietane diterpenoids with anti-inflammatory activities from Clerodendrum bungei and C. inerme
by: Yeling Wu, et al.
Published: (2024-01-01)

Abietan İskeletine Sahip Szemaoenoid A Molekülünün Teorik Olarak İncelenmesi
by: Alper Kaya, et al.
Published: (2022-05-01)

Abietane Diterpenoids Isolated from <i>Clerodendrum bracteatum</i> and Their Antioxidant and Cytotoxic Activities
by: Pingting Li, et al.
Published: (2021-08-01)

Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.
by: Zhen-Hui Wang, et al.
Published: (2017-05-01)

<i>Ent</i>-Abietane Diterpenoids from <i>Euphorbia fischeriana</i> and Their Cytotoxic Activities
by: Qin-Feng Zhu, et al.
Published: (2022-10-01)

Abietane-type diterpenoids from the roots of Salvia tebesana
by: S. Eghbaliferiz*, et al.
Published: (2017-11-01)

Structure, Absolute Configuration, Antiproliferative and Phytotoxic Activities of Icetexane and Abietane Diterpenoids from <i>Salvia carranzae</i> and Chemotaxonomic Implications
by: Celia Bustos-Brito, et al.
Published: (2024-03-01)

Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis via the mitochondria dependent pathway
by: Mariana Magalhães, et al.
Published: (2022-10-01)

Abietane Diterpenes of the Genus <i>Plectranthus sensu lato</i>
by: Mária Gáborová, et al.
Published: (2021-12-01)

Structure, Absolute Configuration, and Antiproliferative Activity of Abietane and Icetexane Diterpenoids from Salvia ballotiflora
by: Baldomero Esquivel, et al.
Published: (2017-10-01)

Cytotoxic ent-abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalis
by: Yanisa Olaranont, et al.
Published: (2024-02-01)

Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from <i>Plectranthus madagascariensis</i>
by: Kadidiatou O. Ndjoubi, et al.
Published: (2021-01-01)

Abietane Diterpenoids from the Hairy Roots of <i>Salvia corrugata</i>
by: Roméo Arago Dougué Kentsop, et al.
Published: (2021-08-01)

Preliminary Biological Activity Screening of <i>Plectranthus</i> spp. Extracts for the Search of Anticancer Lead Molecules
by: Epole Ntungwe, et al.
Published: (2021-04-01)

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from <i>Plectranthus</i> spp.
by: Przemysław Sitarek, et al.
Published: (2020-01-01)

New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities
by: Zilda Cristiani Gazim, et al.
Published: (2014-01-01)

Decandrinin, an unprecedented C9-spiro-fused 7,8-seco-ent-abietane from the Godavari mangrove Ceriops decandra
by: Hui Wang, et al.
Published: (2014-01-01)

In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis
by: Inmaculada Ramírez-Macías, et al.
Published: (2012-05-01)

Abietane-Type Diterpenoids From Nepeta bracteata Benth. and Their Anti-Inflammatory Activity
by: Er-Lan Yang, et al.
Published: (2022-07-01)

Semisynthetic Sesquiterpene Lactones Generated by the Sensibility of Glaucolide B to Lewis and Brønsted–Lowry Acids and Bases: Cytotoxicity and Anti-Inflammatory Activities
by: Layzon A. Lemos da Silva, et al.
Published: (2023-01-01)

Pemigatinib in previously treated Chinese patients with locally advanced or metastatic cholangiocarcinoma carrying FGFR2 fusions or rearrangements: A phase II study
by: Guo‐Ming Shi, et al.
Published: (2023-02-01)

Plectrabarbene, a New Abietane Diterpene from <i>Plectranthus barbatus</i> Aerial Parts
by: Nawal M. Al Musayeib, et al.
Published: (2020-05-01)

Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
by: Juan Liu, et al.
Published: (2017-07-01)

Hydroxide-Mediated S<sub>N</sub>Ar Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents
by: Xiang Yu, et al.
Published: (2023-05-01)

Unprecedented Elimination Reactions of Cyclic Aldols: A New Biosynthetic Pathway toward the Taiwaniaquinoid Skeleton
by: Juan J. Guardia, et al.
Published: (2023-02-01)

Identification of Abietane-Type Diterpenoids and Phenolic Acids Biosynthesis Genes in Salvia apiana Jepson Through Full-Length Transcriptomic and Metabolomic Profiling
by: Jiadong Hu, et al.
Published: (2022-06-01)

Functional Characterization of a 2OGD Involved in Abietane-Type Diterpenoids Biosynthetic Pathway in Salvia miltiorrhiza
by: Zhimin Hu, et al.
Published: (2022-07-01)

Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects
by: Guillermo Schmeda-Hirschmann, et al.
Published: (2013-05-01)

Semisynthesis, an Anti-Inflammatory Effect of Derivatives of 1β-Hydroxy Alantolactone from Inula britannica
by: Lin Chen, et al.
Published: (2017-10-01)

Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway
by: Xiaoqian Ran, et al.
Published: (2023-02-01)

Structural Requirements for Antimicrobial Activity of Phenolic Nor-Triterpenes from Celastraceae Species
by: Laila Moujir, et al.
Published: (2019-07-01)

Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from <i>Euphorbia fischeriana</i> Steud
by: Gang Chen, et al.
Published: (2022-07-01)

Circumdatin-Aspyrone Conjugates from the Coral-Associated <i>Aspergillus ochraceus</i> LCJ11-102
by: Yaqin Fan, et al.
Published: (2019-07-01)

Development and Optimization of the Multi-Gram Synthesis of the Antiviral 18-(Phthalimide-2-yl)ferruginol
by: Francisco Javier Miquel-Leal, et al.
Published: (2021-11-01)

Abietane Diterpenoids Isolated from <i>Torreya nucifera</i> Disrupt Replication of Influenza Virus by Blocking the Phosphatidylinositol-3-Kinase (PI3K)-Akt and ERK Signaling Pathway
by: Jaehoon Bae, et al.
Published: (2023-03-01)

Synthesis of Tricyclic Pterolobirin H Analogue: Evaluation of Anticancer and Anti-Inflammatory Activities and Molecular Docking Investigations
by: Houda Zentar, et al.
Published: (2023-08-01)

Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity
by: Wei-Hua Cheng, et al.
Published: (2015-07-01)