Wound healing - A literature review
Abstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia
2016-10-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/abd/v91n5/0365-0596-abd-91-05-0614.pdf |
| _version_ | 1818743644491874304 |
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| author | Ana Cristina de Oliveira Gonzalez Tila Fortuna Costa Zilton de Araújo Andrade Alena Ribeiro Alves Peixoto Medrado |
| author_facet | Ana Cristina de Oliveira Gonzalez Tila Fortuna Costa Zilton de Araújo Andrade Alena Ribeiro Alves Peixoto Medrado |
| author_sort | Ana Cristina de Oliveira Gonzalez |
| collection | DOAJ |
| description | Abstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process. |
| first_indexed | 2024-12-18T02:31:41Z |
| format | Article |
| id | doaj.art-5d51a6fbd93b4855a81612769a23c6c9 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-18T02:31:41Z |
| publishDate | 2016-10-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-5d51a6fbd93b4855a81612769a23c6c92022-12-21T21:23:53ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962016-10-0191561462010.1590/abd1806-4841.20164741Wound healing - A literature reviewAna Cristina de Oliveira GonzalezTila Fortuna CostaZilton de Araújo AndradeAlena Ribeiro Alves Peixoto MedradoAbstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.http://www.scielo.br/pdf/abd/v91n5/0365-0596-abd-91-05-0614.pdfCell proliferationHedgehog proteinsInflammationWound Healing |
| spellingShingle | Ana Cristina de Oliveira Gonzalez Tila Fortuna Costa Zilton de Araújo Andrade Alena Ribeiro Alves Peixoto Medrado Wound healing - A literature review Anais Brasileiros de Dermatologia Cell proliferation Hedgehog proteins Inflammation Wound Healing |
| title | Wound healing - A literature review |
| title_full | Wound healing - A literature review |
| title_fullStr | Wound healing - A literature review |
| title_full_unstemmed | Wound healing - A literature review |
| title_short | Wound healing - A literature review |
| title_sort | wound healing a literature review |
| topic | Cell proliferation Hedgehog proteins Inflammation Wound Healing |
| url | http://www.scielo.br/pdf/abd/v91n5/0365-0596-abd-91-05-0614.pdf |
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