Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study
BackgroundPain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients’ mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear.ObjectiveThe study aimed to explore the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1309583/full |
| _version_ | 1797341211521974272 |
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| author | Huiying Ouyang Xiaojun Li Haoyou Xu Haoyou Xu Yibo Zhan Zequan Zheng Zequan Zheng Guixian Chen Zhenzhen Lou Haoxuan Chen Jiahui Zhang Jiahui Zhang Hui Mao Changlin Zhang Lulu Qin Yuanqi Zhao Yuanqi Zhao Min Zhao Min Zhao |
| author_facet | Huiying Ouyang Xiaojun Li Haoyou Xu Haoyou Xu Yibo Zhan Zequan Zheng Zequan Zheng Guixian Chen Zhenzhen Lou Haoxuan Chen Jiahui Zhang Jiahui Zhang Hui Mao Changlin Zhang Lulu Qin Yuanqi Zhao Yuanqi Zhao Min Zhao Min Zhao |
| author_sort | Huiying Ouyang |
| collection | DOAJ |
| description | BackgroundPain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients’ mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear.ObjectiveThe study aimed to explore the risk factors of neuropathic pain among MS patients.Materials and methodsThis retrospective study examined the consecutive patients diagnosed with MS in the Department of Neurology of Guangdong Provincial Hospital of Chinese Medicine between August 2011 and October 2022. Neuropathic pain was defined as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system”. Demographic and clinical features were obtained from the electronic system of the hospital.ResultsOur cohort revealed that the prevalence of patients with neuropathic pain in MS was 34.1%. The results indicated that the longer the spinal lesions, the greater the neuropathic pain risks (2-4: OR, 13.3(2.1-82), >5: OR, 15.2(2.7-86.8), p for tread: 0.037). Meanwhile, multivariate regression analysis showed that cervical and thoracic lesions (OR 4.276, 95% CI 1.366-13.382, P = 0.013), upper thoracic lesions (T1-T6) (OR 3.047, 95% CI 1.018-9.124, P = 0.046) were positively correlated with neuropathic pain, while basal ganglia lesions (OR 0.188, 95% CI 0.044-0.809, P = 0.025) were negatively correlated with neuropathic pain among MS patients.ConclusionExtended spinal lesions (≥3 spinal lesions), cervical and thoracic lesions, upper thoracic lesions were independent risk factors of neuropathic pain among MS patients. Furthermore, our study found that the longer the spinal lesions, the greater the neuropathic pain risks. |
| first_indexed | 2024-03-08T10:14:35Z |
| format | Article |
| id | doaj.art-5d523647ca12430b9b0fd077939bbe4f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T10:14:35Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5d523647ca12430b9b0fd077939bbe4f2024-01-29T04:39:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011510.3389/fimmu.2024.13095831309583Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort studyHuiying Ouyang0Xiaojun Li1Haoyou Xu2Haoyou Xu3Yibo Zhan4Zequan Zheng5Zequan Zheng6Guixian Chen7Zhenzhen Lou8Haoxuan Chen9Jiahui Zhang10Jiahui Zhang11Hui Mao12Changlin Zhang13Lulu Qin14Yuanqi Zhao15Yuanqi Zhao16Min Zhao17Min Zhao18The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaBackgroundPain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients’ mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear.ObjectiveThe study aimed to explore the risk factors of neuropathic pain among MS patients.Materials and methodsThis retrospective study examined the consecutive patients diagnosed with MS in the Department of Neurology of Guangdong Provincial Hospital of Chinese Medicine between August 2011 and October 2022. Neuropathic pain was defined as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system”. Demographic and clinical features were obtained from the electronic system of the hospital.ResultsOur cohort revealed that the prevalence of patients with neuropathic pain in MS was 34.1%. The results indicated that the longer the spinal lesions, the greater the neuropathic pain risks (2-4: OR, 13.3(2.1-82), >5: OR, 15.2(2.7-86.8), p for tread: 0.037). Meanwhile, multivariate regression analysis showed that cervical and thoracic lesions (OR 4.276, 95% CI 1.366-13.382, P = 0.013), upper thoracic lesions (T1-T6) (OR 3.047, 95% CI 1.018-9.124, P = 0.046) were positively correlated with neuropathic pain, while basal ganglia lesions (OR 0.188, 95% CI 0.044-0.809, P = 0.025) were negatively correlated with neuropathic pain among MS patients.ConclusionExtended spinal lesions (≥3 spinal lesions), cervical and thoracic lesions, upper thoracic lesions were independent risk factors of neuropathic pain among MS patients. Furthermore, our study found that the longer the spinal lesions, the greater the neuropathic pain risks.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1309583/fullspinal cord lesionsbasal gangliamultiple sclerosisneuropathic painMRI |
| spellingShingle | Huiying Ouyang Xiaojun Li Haoyou Xu Haoyou Xu Yibo Zhan Zequan Zheng Zequan Zheng Guixian Chen Zhenzhen Lou Haoxuan Chen Jiahui Zhang Jiahui Zhang Hui Mao Changlin Zhang Lulu Qin Yuanqi Zhao Yuanqi Zhao Min Zhao Min Zhao Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study Frontiers in Immunology spinal cord lesions basal ganglia multiple sclerosis neuropathic pain MRI |
| title | Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study |
| title_full | Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study |
| title_fullStr | Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study |
| title_full_unstemmed | Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study |
| title_short | Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study |
| title_sort | risk factors of neuropathic pain in multiple sclerosis a retrospective case cohort study |
| topic | spinal cord lesions basal ganglia multiple sclerosis neuropathic pain MRI |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1309583/full |
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