Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis

Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis

Non-alcoholic fatty liver disease (NAFLD), characterized by fat accumulation in liver, is closely associated with central obesity, over-nutrition and other features of metabolic syndrome, which elevate the risk of developing hepatocellular carcinoma (HCC). The Wnt/β-catenin signaling pathway plays a...

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Bibliographic Details
Main Authors: Yuan Tian, Myth T.S. Mok, Pengyuan Yang, Alfred S.L. Cheng
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Cancers
Subjects:
non-alcoholic fatty liver disease
hepatocellular carcinoma
Wnt
β-catenin
epigenetics
DNA methylation
histone modification
microRNA
HDAC8
Online Access:http://www.mdpi.com/2072-6694/8/8/76

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