SinoDuplex: An Improved Duplex Sequencing Approach to Detect Low-frequency Variants in Plasma cfDNA Samples

SinoDuplex: An Improved Duplex Sequencing Approach to Detect Low-frequency Variants in Plasma cfDNA Samples

Accurate detection of low frequency mutations from plasma cell-free DNA in blood using targeted next generation sequencing technology has shown promising benefits in clinical settings. Duplex sequencing technology is the most commonly used approach in liquid biopsies. Unique molecular identifiers ar...

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Bibliographic Details
Main Authors: Yongzhe Ren, Yang Zhang, Dandan Wang, Fengying Liu, Ying Fu, Shaohua Xiang, Li Su, Jiancheng Li, Heng Dai, Bingding Huang
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Next generation sequencing
Liquid biopsy
Circulating tumor DNA
Duplex sequencing
Low frequency variant
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022920300541

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