Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.

Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.

Rare inherited cardiovascular diseases are frequently caused by mutations in genes that are essential for the formation and/or function of the cardiovasculature. Hereditary Haemorrhagic Telangiectasia is a familial disease of this type. The majority of patients carry mutations in either Endoglin (EN...

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Bibliographic Details
Main Authors: Simon Tual-Chalot, Marwa Mahmoud, Kathleen R Allinson, Rachael E Redgrave, Zhenhua Zhai, S Paul Oh, Marcus Fruttiger, Helen M Arthur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4045906?pdf=render

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