Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients.
The objective of this study was to explore predictors, including social factors, lifestyle factors, and factors relevant to glycemic control and treatment, for mild and severe hypoglycemia in insulin-treated Japanese diabetic patients. This study included 123 insulin-treated diabetic patients who we...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4477874?pdf=render |
| _version_ | 1819274216603648000 |
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| author | Nao Sonoda Akiko Morimoto Satoshi Ugi Katsutaro Morino Osamu Sekine Ken-Ichi Nemoto Kayo Godai Hiroshi Maegawa Naomi Miyamatsu |
| author_facet | Nao Sonoda Akiko Morimoto Satoshi Ugi Katsutaro Morino Osamu Sekine Ken-Ichi Nemoto Kayo Godai Hiroshi Maegawa Naomi Miyamatsu |
| author_sort | Nao Sonoda |
| collection | DOAJ |
| description | The objective of this study was to explore predictors, including social factors, lifestyle factors, and factors relevant to glycemic control and treatment, for mild and severe hypoglycemia in insulin-treated Japanese diabetic patients. This study included 123 insulin-treated diabetic patients who were referred to the diabetes clinic between January and July 2013 at Shiga University of Medical Science Hospital. After a survey examining the various factors, patients were followed for 6 months. During the follow-up period, blood glucose was self-monitored. Mild hypoglycemia was defined as blood glucose level 50-69 mg/dl, and severe hypoglycemia was defined as blood glucose level ≤49 mg/dl. Multinomial logistic regression was used to estimate the adjusted odds ratio (OR) and 95% confidence interval (CI) of each factor for mild and severe hypoglycemia. During the 6-month follow-up period, 41 (33.3%) patients experienced mild hypoglycemia, and 20 (16.3%) experienced severe hypoglycemia. In multivariable-adjusted analyses, assistance from family members at the time of the insulin injection [presence/absence, OR (95% CI): 0.39 (0.16-0.97)] and drinking [current drinker/non- and ex-drinker, OR (95% CI): 4.89 (1.68-14.25)] affected mild hypoglycemia. Assistance from family members at the time of insulin injection [presence/absence, OR (95% CI): 0.19 (0.05-0.75)] and intensive insulin therapy [yes/no, OR (95% CI): 3.61 (1.06-12.26)] affected severe hypoglycemia. In conclusion, our findings suggest that not only a factor relevant to glycemic control and treatment (intensive insulin therapy) but also a social factor (assistance from family members) and a lifestyle factor (current drinking) were predictors for mild or severe hypoglycemia in Japanese insulin-treated diabetic patients. |
| first_indexed | 2024-12-23T23:04:54Z |
| format | Article |
| id | doaj.art-5d531cae38644db582e01ee3f77f3432 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:04:54Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5d531cae38644db582e01ee3f77f34322022-12-21T17:26:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013058410.1371/journal.pone.0130584Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients.Nao SonodaAkiko MorimotoSatoshi UgiKatsutaro MorinoOsamu SekineKen-Ichi NemotoKayo GodaiHiroshi MaegawaNaomi MiyamatsuThe objective of this study was to explore predictors, including social factors, lifestyle factors, and factors relevant to glycemic control and treatment, for mild and severe hypoglycemia in insulin-treated Japanese diabetic patients. This study included 123 insulin-treated diabetic patients who were referred to the diabetes clinic between January and July 2013 at Shiga University of Medical Science Hospital. After a survey examining the various factors, patients were followed for 6 months. During the follow-up period, blood glucose was self-monitored. Mild hypoglycemia was defined as blood glucose level 50-69 mg/dl, and severe hypoglycemia was defined as blood glucose level ≤49 mg/dl. Multinomial logistic regression was used to estimate the adjusted odds ratio (OR) and 95% confidence interval (CI) of each factor for mild and severe hypoglycemia. During the 6-month follow-up period, 41 (33.3%) patients experienced mild hypoglycemia, and 20 (16.3%) experienced severe hypoglycemia. In multivariable-adjusted analyses, assistance from family members at the time of the insulin injection [presence/absence, OR (95% CI): 0.39 (0.16-0.97)] and drinking [current drinker/non- and ex-drinker, OR (95% CI): 4.89 (1.68-14.25)] affected mild hypoglycemia. Assistance from family members at the time of insulin injection [presence/absence, OR (95% CI): 0.19 (0.05-0.75)] and intensive insulin therapy [yes/no, OR (95% CI): 3.61 (1.06-12.26)] affected severe hypoglycemia. In conclusion, our findings suggest that not only a factor relevant to glycemic control and treatment (intensive insulin therapy) but also a social factor (assistance from family members) and a lifestyle factor (current drinking) were predictors for mild or severe hypoglycemia in Japanese insulin-treated diabetic patients.http://europepmc.org/articles/PMC4477874?pdf=render |
| spellingShingle | Nao Sonoda Akiko Morimoto Satoshi Ugi Katsutaro Morino Osamu Sekine Ken-Ichi Nemoto Kayo Godai Hiroshi Maegawa Naomi Miyamatsu Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients. PLoS ONE |
| title | Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients. |
| title_full | Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients. |
| title_fullStr | Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients. |
| title_full_unstemmed | Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients. |
| title_short | Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients. |
| title_sort | predictors for mild and severe hypoglycemia in insulin treated japanese diabetic patients |
| url | http://europepmc.org/articles/PMC4477874?pdf=render |
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