Advances in molecular mechanism of bladder detrusor dysfunction
Bladder outlet obstruction (BOO) increases micturition resistance and prolongs the duration of intravesical hypertension. The intravesical pressure overloads the hydrostatic pressure and mechanical tensile force of detrusor,which triggers the cascade reaction of muscle cells starting from mechanical...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-10-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1606.pdf |
| _version_ | 1797365853030711296 |
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| author | LIU Sheng-lai, TIAN Da-wei, WU Chang-li |
| author_facet | LIU Sheng-lai, TIAN Da-wei, WU Chang-li |
| author_sort | LIU Sheng-lai, TIAN Da-wei, WU Chang-li |
| collection | DOAJ |
| description | Bladder outlet obstruction (BOO) increases micturition resistance and prolongs the duration of intravesical hypertension. The intravesical pressure overloads the hydrostatic pressure and mechanical tensile force of detrusor,which triggers the cascade reaction of muscle cells starting from mechanical tension stress, hypoxia and ischemia-reperfusion injury (IRI), leading to changes in intracellular metabolism and reconstruction of extracellular matrix.The change of interstitial components is irreversible injury, and there is no effective treatment measures in the decompensation stage. At present, the exact pathogenesis is not completely clear. The study on the pathogenesis of BOO may support early detection of obstructive dysuria, which is of great significance for clinical treatment. |
| first_indexed | 2024-03-08T16:54:54Z |
| format | Article |
| id | doaj.art-5d55527da34342e79ce1d8f8b6184dd8 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:54:54Z |
| publishDate | 2022-10-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-5d55527da34342e79ce1d8f8b6184dd82024-01-05T02:36:29ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-10-0142101606161010.16352/j.issn.1001-6325.2022.10.1606Advances in molecular mechanism of bladder detrusor dysfunctionLIU Sheng-lai, TIAN Da-wei, WU Chang-li01. Department of Urology, the Second Hospital of Tianjin Medical University/Tianjin Key Laboratory of Basic Urology/Tianjin Urology Institute, Tianjin 300211; ;2. Department of Urology, Sino-Singapore Eco-City Hospital of Tianjin Medical University, Tianjin 300467, ChinaBladder outlet obstruction (BOO) increases micturition resistance and prolongs the duration of intravesical hypertension. The intravesical pressure overloads the hydrostatic pressure and mechanical tensile force of detrusor,which triggers the cascade reaction of muscle cells starting from mechanical tension stress, hypoxia and ischemia-reperfusion injury (IRI), leading to changes in intracellular metabolism and reconstruction of extracellular matrix.The change of interstitial components is irreversible injury, and there is no effective treatment measures in the decompensation stage. At present, the exact pathogenesis is not completely clear. The study on the pathogenesis of BOO may support early detection of obstructive dysuria, which is of great significance for clinical treatment.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1606.pdfbladder outlet obstruction|bladder remodeling|urothelial fibrosis|smooth muscle |
| spellingShingle | LIU Sheng-lai, TIAN Da-wei, WU Chang-li Advances in molecular mechanism of bladder detrusor dysfunction Jichu yixue yu linchuang bladder outlet obstruction|bladder remodeling|urothelial fibrosis|smooth muscle |
| title | Advances in molecular mechanism of bladder detrusor dysfunction |
| title_full | Advances in molecular mechanism of bladder detrusor dysfunction |
| title_fullStr | Advances in molecular mechanism of bladder detrusor dysfunction |
| title_full_unstemmed | Advances in molecular mechanism of bladder detrusor dysfunction |
| title_short | Advances in molecular mechanism of bladder detrusor dysfunction |
| title_sort | advances in molecular mechanism of bladder detrusor dysfunction |
| topic | bladder outlet obstruction|bladder remodeling|urothelial fibrosis|smooth muscle |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-10-1606.pdf |
| work_keys_str_mv | AT liushenglaitiandaweiwuchangli advancesinmolecularmechanismofbladderdetrusordysfunction |