Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1
Abstract Background We report the first case of acute hemorrhagic cholecystitis with large hemoperitoneum related to gallbladder wall fragility caused by neurofibroma cell infiltration. Case presentation A 46-year-old man with neurofibromatosis type 1 (NF1), who had been hospitalized for retroperito...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | Surgical Case Reports |
| Online Access: | https://doi.org/10.1186/s40792-023-01647-2 |
| _version_ | 1797840852594196480 |
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| author | Takeshi Omura Koichi Ikawa Eiji Kudo |
| author_facet | Takeshi Omura Koichi Ikawa Eiji Kudo |
| author_sort | Takeshi Omura |
| collection | DOAJ |
| description | Abstract Background We report the first case of acute hemorrhagic cholecystitis with large hemoperitoneum related to gallbladder wall fragility caused by neurofibroma cell infiltration. Case presentation A 46-year-old man with neurofibromatosis type 1 (NF1), who had been hospitalized for retroperitoneal hematoma and treated by transarterial embolization 9 days earlier, complained of right upper quadrant pain, bloating, nausea, and emesis. Computed tomography revealed fluid collection and a distended gallbladder with high-density contents. The patient was taken to the operating room for laparoscopic cholecystectomy, with consideration of the hemodynamic tolerance, for acute hemorrhagic cholecystitis. An initial laparoscopy revealed a significant amount of blood in the abdominal cavity exuding from the gallbladder. Due to its fragility, the gallbladder was easily ruptured by surgical manipulation. After conversion to open surgery, subtotal cholecystectomy was performed. Seventeen days after surgery, the patient was transferred to another hospital for rehabilitation. Histological examination revealed diffuse and nodular proliferation of spindle cells that had replaced the muscularis propria of the gallbladder wall. Conclusion This clinical case highlights how NF1 can cause various symptoms in the blood vessels and gastrointestinal tract, including the gallbladder. |
| first_indexed | 2024-04-09T16:21:30Z |
| format | Article |
| id | doaj.art-5d577633c91c44caac14593861b52a1a |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-04-09T16:21:30Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-5d577633c91c44caac14593861b52a1a2023-04-23T11:26:36ZengSpringerOpenSurgical Case Reports2198-77932023-04-01911610.1186/s40792-023-01647-2Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1Takeshi Omura0Koichi Ikawa1Eiji Kudo2Department of Surgery, Tokushima Prefectural Central HospitalDepartment of Surgery, Tokushima Prefectural Central HospitalDepartment of Pathology, Tokushima Prefectural Central HospitalAbstract Background We report the first case of acute hemorrhagic cholecystitis with large hemoperitoneum related to gallbladder wall fragility caused by neurofibroma cell infiltration. Case presentation A 46-year-old man with neurofibromatosis type 1 (NF1), who had been hospitalized for retroperitoneal hematoma and treated by transarterial embolization 9 days earlier, complained of right upper quadrant pain, bloating, nausea, and emesis. Computed tomography revealed fluid collection and a distended gallbladder with high-density contents. The patient was taken to the operating room for laparoscopic cholecystectomy, with consideration of the hemodynamic tolerance, for acute hemorrhagic cholecystitis. An initial laparoscopy revealed a significant amount of blood in the abdominal cavity exuding from the gallbladder. Due to its fragility, the gallbladder was easily ruptured by surgical manipulation. After conversion to open surgery, subtotal cholecystectomy was performed. Seventeen days after surgery, the patient was transferred to another hospital for rehabilitation. Histological examination revealed diffuse and nodular proliferation of spindle cells that had replaced the muscularis propria of the gallbladder wall. Conclusion This clinical case highlights how NF1 can cause various symptoms in the blood vessels and gastrointestinal tract, including the gallbladder.https://doi.org/10.1186/s40792-023-01647-2 |
| spellingShingle | Takeshi Omura Koichi Ikawa Eiji Kudo Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 Surgical Case Reports |
| title | Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 |
| title_full | Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 |
| title_fullStr | Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 |
| title_full_unstemmed | Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 |
| title_short | Acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 |
| title_sort | acute hemorrhagic cholecystitis related to diffuse neurofibroma of gallbladder in a patient with neurofibromatosis type 1 |
| url | https://doi.org/10.1186/s40792-023-01647-2 |
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