Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk
PURPOSE Heart-type fatty acid binding protein (H-FABP) is a sensitive marker of myocardial injury and predictor of worse prognosis in patients with pulmonary embolism (PE). Assessment of right ventricular dysfunction and pulmonary artery obstruction index (PAOI) with computed tomography (CT) has bee...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2013-02-01
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| Series: | Diagnostic and Interventional Radiology |
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| Online Access: | http://www.dirjournal.org/summary_en.php3?id=474 |
| _version_ | 1827832522065575936 |
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| author | Kurtuluş Özdemir Mehmet Kayrak Turyan Abdülhalikov Ahmet Yeşildağ İbrahim Güler İlknur Can Enes Elvin Gül Hasan Gök |
| author_facet | Kurtuluş Özdemir Mehmet Kayrak Turyan Abdülhalikov Ahmet Yeşildağ İbrahim Güler İlknur Can Enes Elvin Gül Hasan Gök |
| author_sort | Kurtuluş Özdemir |
| collection | DOAJ |
| description | PURPOSE Heart-type fatty acid binding protein (H-FABP) is a sensitive marker of myocardial injury and predictor of worse prognosis in patients with pulmonary embolism (PE). Assessment of right ventricular dysfunction and pulmonary artery obstruction index (PAOI) with computed tomography (CT) has been reported as a predictor of mortality in PE. Therefore, we aimed to assess the correlation between H-FABP and CT angiographic PAOI in PE patients at intermediate risk. MATERIALS AND METHODS Sixty-one patients (28 males; mean age, 62±17 years) with diagnosis of PE were included in this study. CT was performed in all patients, and the following parameters were evaluated: right ventricle/left ventricle ratio (RV/LV), pulmonary artery axial diameter, superior vena cava axial diameter, and PAOI determined with Qanadli score. Blood samples were assessed for H-FABP and troponin levels. Patients were followed for 30 days after discharge. RESULTS Mean PAOI was 57±18%. Eleven patients died during the follow-up period due to PE (18% mortality rate). H-FABP was positive in 21 patients (35%). There was no difference in CT parameters between patients with positive H-FABP and negative H-FABP. In addition, CT parameters were similar between patients who survived and those who did not. RV/LV ratio correlated with PAOI score. Among the biomarkers, troponin levels correlated with both RV/LV ratio and PAOI. H-FABP was an independent predictor of mortality. PAOI and RV/LV ratio did not predict 30-day mortality. CONCLUSIONAlthough H-FABP positivity confers a bad prognosis on PE patients at intermediate risk, PAOI did not predict mortality in this group. |
| first_indexed | 2024-03-12T05:14:39Z |
| format | Article |
| id | doaj.art-5d57ab006b6042a989f19992c2e9b821 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T05:14:39Z |
| publishDate | 2013-02-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-5d57ab006b6042a989f19992c2e9b8212023-09-03T08:19:16ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122013-02-01186531536Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate riskKurtuluş ÖzdemirMehmet KayrakTuryan AbdülhalikovAhmet Yeşildağİbrahim Gülerİlknur CanEnes Elvin GülHasan GökPURPOSE Heart-type fatty acid binding protein (H-FABP) is a sensitive marker of myocardial injury and predictor of worse prognosis in patients with pulmonary embolism (PE). Assessment of right ventricular dysfunction and pulmonary artery obstruction index (PAOI) with computed tomography (CT) has been reported as a predictor of mortality in PE. Therefore, we aimed to assess the correlation between H-FABP and CT angiographic PAOI in PE patients at intermediate risk. MATERIALS AND METHODS Sixty-one patients (28 males; mean age, 62±17 years) with diagnosis of PE were included in this study. CT was performed in all patients, and the following parameters were evaluated: right ventricle/left ventricle ratio (RV/LV), pulmonary artery axial diameter, superior vena cava axial diameter, and PAOI determined with Qanadli score. Blood samples were assessed for H-FABP and troponin levels. Patients were followed for 30 days after discharge. RESULTS Mean PAOI was 57±18%. Eleven patients died during the follow-up period due to PE (18% mortality rate). H-FABP was positive in 21 patients (35%). There was no difference in CT parameters between patients with positive H-FABP and negative H-FABP. In addition, CT parameters were similar between patients who survived and those who did not. RV/LV ratio correlated with PAOI score. Among the biomarkers, troponin levels correlated with both RV/LV ratio and PAOI. H-FABP was an independent predictor of mortality. PAOI and RV/LV ratio did not predict 30-day mortality. CONCLUSIONAlthough H-FABP positivity confers a bad prognosis on PE patients at intermediate risk, PAOI did not predict mortality in this group.http://www.dirjournal.org/summary_en.php3?id=474pulmonary embolismheart-type fatty acid-binding proteincomputed tomographypulmonary artery obstructioninde |
| spellingShingle | Kurtuluş Özdemir Mehmet Kayrak Turyan Abdülhalikov Ahmet Yeşildağ İbrahim Güler İlknur Can Enes Elvin Gül Hasan Gök Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk Diagnostic and Interventional Radiology pulmonary embolism heart-type fatty acid-binding protein computed tomography pulmonary artery obstructioninde |
| title | Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk |
| title_full | Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk |
| title_fullStr | Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk |
| title_full_unstemmed | Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk |
| title_short | Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk |
| title_sort | association of pulmonary artery obstruction index with elevated heart type fatty acid binding protein and short term mortality in patients with pulmonary embolism at intermediate risk |
| topic | pulmonary embolism heart-type fatty acid-binding protein computed tomography pulmonary artery obstructioninde |
| url | http://www.dirjournal.org/summary_en.php3?id=474 |
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