Comparison of IL‐2‐antibody to IL‐2‐Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors

Comparison of IL‐2‐antibody to IL‐2‐Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors

Abstract Background The potent immune effects of interleukin‐2 (IL‐2) for cancer therapy can be increased by genetic fusion of IL‐2 to the Fc domain of an antibody (IL‐2‐Fc) or tumor targeted by genetic fusion to a whole antibody known as an immunocytokine (ICK). Methods An anti‐CEA ICK (M5A‐IL‐2) w...

Full description

Bibliographic Details
Main Authors:	Lindsay Williams, Lin Li, Paul J. Yazaki, Patty Wong, Teresa Hong, Erasmus K. Poku, Susanta Hui, Hemendra Ghimire, John E. Shively, Maciej Kujawski
Format:	Article
Language:	English
Published:	Wiley 2024-02-01
Series:	Cancer Medicine
Subjects:	breast cancer colon cancer immunocytokines immunotherapy radiation therapy
Online Access:	https://doi.org/10.1002/cam4.6909

Similar Items

Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation
by: Maciej Kujawski, et al.
Published: (2020-01-01)

Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokine
by: Seung E. Cha, et al.
Published: (2021-01-01)

Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
by: Christian Klein, et al.
Published: (2017-03-01)

Human and murine IL2 receptors differentially respond to the human-IL2 component of immunocytokines
by: Zulmarie Perez Horta, et al.
Published: (2019-06-01)

GT-00AxIL15, a Novel Tumor-Targeted IL-15-Based Immunocytokine for the Treatment of TA-MUC1-Positive Solid Tumors: Preclinical In Vitro and In Vivo Pharmacodynamics and Biodistribution Studies
by: Johanna Gellert, et al.
Published: (2024-01-01)

CEA vaccines
by: Anchit Bhagat, et al.
Published: (2023-12-01)

Potent immunomodulatory and antitumor effect of anti-CD20-IL2no-alpha tri-functional immunocytokine for cancer therapy
by: Ana Victoria Casadesús, et al.
Published: (2022-12-01)

The role of serum IL-6 in colorectal cancer patients and it’s relationship with serum CEA level
by: Batool H. Al-Ghurabi, et al.
Published: (2010-01-01)

The prognostic value of the postoperative serum CEA levels/preoperative serum CEA levels ratio in colorectal cancer patients with high preoperative serum CEA levels
by: Xie HL, et al.
Published: (2019-08-01)

The Carcinoembryonic Antigen (CEA): Past, Present, and Future
by: Phil Gold, et al.
Published: (2020-12-01)

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo
by: Franziska Eckert, et al.
Published: (2017-06-01)

CEA as a prognostic index in colorectal cancer
by: Nora Manoukian Forones, et al.

Utilizing Immunocytokines for Cancer Therapy
by: Erin Runbeck, et al.
Published: (2021-03-01)

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice
by: Riikka Viitanen, et al.
Published: (2022-07-01)

Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
by: Inja Waldhauer, et al.
Published: (2021-01-01)

Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy
by: Keunok Jung, et al.
Published: (2022-10-01)

Effect of UBE2Q on BECN and CEA Protein in Colorectal Cancer Cells
by: Niloofar Boroumand
Published: (2018-12-01)

Multivariate Analysis of Prognostic Determinants for Colorectal Cancer Patients with High Preoperative Serum CEA Levels: Prognostic Value of Postoperative Serum CEA Levels
by: Cheng-Jen Ma, et al.
Published: (2006-12-01)

Delay to CEA
by: Christopher Nwatuzor, et al.
Published: (2024-01-01)

Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects
by: Vladislav S. Rybchenko, et al.
Published: (2023-01-01)

NHS-IL12 and bintrafusp alfa combination therapy enhances antitumor activity in preclinical cancer models
by: Chunxiao Xu, et al.
Published: (2022-02-01)

Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation
by: Christian Ilantzis, et al.
Published: (2002-01-01)

CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer
by: Ziba Veisi Malekshahi, et al.
Published: (2019-09-01)

Immunocytokines
by: Katrin L. Gutbrodt, et al.
Published: (2012-05-01)

Clinical Significances of Positive Postoperative Serum CEA and Post-preoperative CEA Increment in Stage II and III Colorectal Cancer: A Multicenter Retrospective Study
by: Weiqiang You, et al.
Published: (2020-05-01)

Cyclophosphamide augments the efficacy of in situ vaccination in a mouse melanoma model
by: Noah Tsarovsky, et al.
Published: (2023-09-01)

Raised CA19–9 and CEA have prognostic relevance in gallbladder carcinoma
by: Ashish Sachan, et al.
Published: (2020-08-01)

A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic
by: Arezoo Beig Parikhani, et al.
Published: (2024-02-01)

Combined detection of serum IL-6 and CEA contributes to the diagnosis of lung adenocarcinoma in situ
by: Jing Pan, et al.
Published: (2024-03-01)

Case Report: Carcinoembryonic Antigen (CEA) in Postoperative Follow-up and Treatment Monitoring of Colorectal Adenocarcinoma
by: Kursteen Price, et al.
Published: (2020-12-01)

Association of T Stage and Serum CEA Levels in Determining Survival of Rectal Cancer
by: Shengwen Wu, et al.
Published: (2020-01-01)

The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients
by: Ping Yu, et al.
Published: (2018-11-01)

PET-CT in oesophageal cancer management: a cost effectiveness analysis (CEA) / Nor Aniza Azmi
by: Azmi, Nor Aniza
Published: (2018)

Generation and in vivo characterization of a novel high-affinity human antibody targeting carcinoembryonic antigen
by: Louis Plüss, et al.
Published: (2023-12-01)

Engineering cytokines for cancer immunotherapy: a systematic review
by: Yong Fu, et al.
Published: (2023-07-01)

Dielectrophoresis-Based Biosensor for Detection of the Cancer Biomarkers CEA and CA 242 in Serum
by: Fleming Dackson Gudagunti, et al.
Published: (2022-03-01)

Diagnostic Value of Combining miRNAs, CEA Measurement and the FOBT in Colorectal Cancer Screening
by: Li X, et al.
Published: (2020-04-01)

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
by: Reyes Gonzalez-Exposito, et al.
Published: (2019-04-01)

A novel multifunctional anti-CEA-IL15 molecule displays potent antitumor activities
by: Liu Y, et al.
Published: (2018-08-01)

Clinical Associations of Preoperative and Postoperative Serum CEA and Lung Cancer Outcome
by: Zonglin Jiao, et al.
Published: (2021-10-01)