Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia
<p>Abstract</p> <p>Background</p> <p>The occurrence of aberrant functional connectivity in the neuronal circuit is one of the integrative theories of the etiology of schizophrenia. Previous studies have reported that the protein and mRNA levels of the synapsin 2 (<it...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-08-01
|
| Series: | Behavioral and Brain Functions |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/1/1/15 |
| _version_ | 1818020587204771840 |
|---|---|
| author | Chung Joo-Ho Park Jin Kyoung Hong Mi Suk Jin Sheng-Yu Kim Jong Woo Song Ji Young Lee Hee Jae Shibata Hiroki Fukumaki Yasuyuki |
| author_facet | Chung Joo-Ho Park Jin Kyoung Hong Mi Suk Jin Sheng-Yu Kim Jong Woo Song Ji Young Lee Hee Jae Shibata Hiroki Fukumaki Yasuyuki |
| author_sort | Chung Joo-Ho |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The occurrence of aberrant functional connectivity in the neuronal circuit is one of the integrative theories of the etiology of schizophrenia. Previous studies have reported that the protein and mRNA levels of the synapsin 2 (<it>SYN2</it>) and complexin 2 (<it>CPLX2</it>) genes were decreased in patients with schizophrenia. Synapsin 2 and complexin 2 are involved in synaptogenesis and the modulation of neurotransmitter release. This report presents a study of the association of polymorphisms of <it>SYN2 </it>and <it>CPLX2 </it>with schizophrenia in the Korean population.</p> <p>Methods</p> <p>Six single nucleotide polymorphisms (SNPs) and one 5-bp insertion/deletion in <it>SYN2 </it>and five SNPs in <it>CPLX2 </it>were genotyped in 154 Korean patients with schizophrenia and 133 control patients using direct sequencing or restriction fragment length polymorphism analysis. An intermarker linkage disequilibrium map was constructed for each gene.</p> <p>Results</p> <p>Although there was no significant difference in the genotypic distributions and allelic frequencies of either <it>SYN2 </it>or <it>CPLX2 </it>polymorphisms between the schizophrenia and control groups, the two-way haplotype analyses revealed significant associations with the disease (<it>P </it>< 0.05 after Bonferroni correction). The three-way haplotype analyses also revealed a significant association of <it>SYN2 </it>with schizophrenia (<it>P </it>< 0.001 after Bonferroni correction).</p> <p>Conclusion</p> <p>These results suggest that both <it>SYN2 </it>and <it>CPLX2 </it>may confer susceptibility to schizophrenia in the Korean population.</p> |
| first_indexed | 2024-04-14T08:07:07Z |
| format | Article |
| id | doaj.art-5d597eed58b246a59e41435a118f0dc6 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-04-14T08:07:07Z |
| publishDate | 2005-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-5d597eed58b246a59e41435a118f0dc62022-12-22T02:04:41ZengBMCBehavioral and Brain Functions1744-90812005-08-01111510.1186/1744-9081-1-15Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophreniaChung Joo-HoPark Jin KyoungHong Mi SukJin Sheng-YuKim Jong WooSong Ji YoungLee Hee JaeShibata HirokiFukumaki Yasuyuki<p>Abstract</p> <p>Background</p> <p>The occurrence of aberrant functional connectivity in the neuronal circuit is one of the integrative theories of the etiology of schizophrenia. Previous studies have reported that the protein and mRNA levels of the synapsin 2 (<it>SYN2</it>) and complexin 2 (<it>CPLX2</it>) genes were decreased in patients with schizophrenia. Synapsin 2 and complexin 2 are involved in synaptogenesis and the modulation of neurotransmitter release. This report presents a study of the association of polymorphisms of <it>SYN2 </it>and <it>CPLX2 </it>with schizophrenia in the Korean population.</p> <p>Methods</p> <p>Six single nucleotide polymorphisms (SNPs) and one 5-bp insertion/deletion in <it>SYN2 </it>and five SNPs in <it>CPLX2 </it>were genotyped in 154 Korean patients with schizophrenia and 133 control patients using direct sequencing or restriction fragment length polymorphism analysis. An intermarker linkage disequilibrium map was constructed for each gene.</p> <p>Results</p> <p>Although there was no significant difference in the genotypic distributions and allelic frequencies of either <it>SYN2 </it>or <it>CPLX2 </it>polymorphisms between the schizophrenia and control groups, the two-way haplotype analyses revealed significant associations with the disease (<it>P </it>< 0.05 after Bonferroni correction). The three-way haplotype analyses also revealed a significant association of <it>SYN2 </it>with schizophrenia (<it>P </it>< 0.001 after Bonferroni correction).</p> <p>Conclusion</p> <p>These results suggest that both <it>SYN2 </it>and <it>CPLX2 </it>may confer susceptibility to schizophrenia in the Korean population.</p>http://www.behavioralandbrainfunctions.com/content/1/1/15 |
| spellingShingle | Chung Joo-Ho Park Jin Kyoung Hong Mi Suk Jin Sheng-Yu Kim Jong Woo Song Ji Young Lee Hee Jae Shibata Hiroki Fukumaki Yasuyuki Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia Behavioral and Brain Functions |
| title | Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia |
| title_full | Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia |
| title_fullStr | Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia |
| title_full_unstemmed | Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia |
| title_short | Association study of polymorphisms in synaptic vesicle-associated genes, <it>SYN2 </it>and <it>CPLX2</it>, with schizophrenia |
| title_sort | association study of polymorphisms in synaptic vesicle associated genes it syn2 it and it cplx2 it with schizophrenia |
| url | http://www.behavioralandbrainfunctions.com/content/1/1/15 |
| work_keys_str_mv | AT chungjooho associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT parkjinkyoung associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT hongmisuk associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT jinshengyu associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT kimjongwoo associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT songjiyoung associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT leeheejae associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT shibatahiroki associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia AT fukumakiyasuyuki associationstudyofpolymorphismsinsynapticvesicleassociatedgenesitsyn2itanditcplx2itwithschizophrenia |