A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment

A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment

Abstract HIV infection compromises both the peripheral and central immune systems due to its pathogenic and neuropathogenic features. The mechanisms driving HIV-1 pathogenesis and neuropathogenesis involve a series of events, including metabolic dysregulation. Furthermore, HIV-subtype-specific varia...

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Hlavní autoři: Levanco Keegan Asia, Esmé Jansen Van Vuren, Zander Lindeque, Monray Edward Williams
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-02-01
Edice:Virology Journal
Témata:
Tryptophan-Kynurenine pathway
Metabolism
Inflammation
Pathogenesis
Neuropathogenesis
On-line přístup:https://doi.org/10.1186/s12985-024-02313-1

Internet

https://doi.org/10.1186/s12985-024-02313-1

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