Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice

Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice

Abstract Nav1.8-positive afferent fibers are mostly nociceptors playing a role in mediating thermal and mechanical pain, but mechanoreceptors within these afferents have not been fully investigated. In this study, we generated mice expressing channel rhodopsin 2 (ChR2) in Nav1.8-positive afferents (...

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Bibliographic Details
Main Authors: Akihiro Yamada, Ayaka I. Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo, Jianguo G. Gu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Brain
Subjects:
Nav1.8
Optogenetics
Opto-tagged single-fiber recording
High threshold mechanoreceptors (HTMRs)
Low threshold mechanoreceptors (LTMRs)
Touch
Online Access:https://doi.org/10.1186/s13041-023-01015-z

Internet

https://doi.org/10.1186/s13041-023-01015-z

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