Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment
Abstract Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-019-0488-9 |
| _version_ | 1811303258588708864 |
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| author | Wen-qing Zhu Shui-yi Shao Li-na Xu Wan-qing Chen Xiao-yu Yu Kai-ming Tang Ze-hua Tang Fa-ming Zhang Jing Qiu |
| author_facet | Wen-qing Zhu Shui-yi Shao Li-na Xu Wan-qing Chen Xiao-yu Yu Kai-ming Tang Ze-hua Tang Fa-ming Zhang Jing Qiu |
| author_sort | Wen-qing Zhu |
| collection | DOAJ |
| description | Abstract Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive H2O2. Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry. |
| first_indexed | 2024-04-13T07:43:38Z |
| format | Article |
| id | doaj.art-5d5c4d562713483ab3a95284381ecde3 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T07:43:38Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-5d5c4d562713483ab3a95284381ecde32022-12-22T02:55:47ZengBMCJournal of Nanobiotechnology1477-31552019-04-0117111810.1186/s12951-019-0488-9Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironmentWen-qing Zhu0Shui-yi Shao1Li-na Xu2Wan-qing Chen3Xiao-yu Yu4Kai-ming Tang5Ze-hua Tang6Fa-ming Zhang7Jing Qiu8Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityJiangsu Key Laboratory for Advanced Metallic Materials, Southeast UniversityDepartment of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical UniversityAbstract Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive H2O2. Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry.http://link.springer.com/article/10.1186/s12951-019-0488-9TitaniumCorrosion behaviorOxidizing conditionMacrophage |
| spellingShingle | Wen-qing Zhu Shui-yi Shao Li-na Xu Wan-qing Chen Xiao-yu Yu Kai-ming Tang Ze-hua Tang Fa-ming Zhang Jing Qiu Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment Journal of Nanobiotechnology Titanium Corrosion behavior Oxidizing condition Macrophage |
| title | Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment |
| title_full | Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment |
| title_fullStr | Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment |
| title_full_unstemmed | Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment |
| title_short | Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment |
| title_sort | enhanced corrosion resistance of zinc containing nanowires modified titanium surface under exposure to oxidizing microenvironment |
| topic | Titanium Corrosion behavior Oxidizing condition Macrophage |
| url | http://link.springer.com/article/10.1186/s12951-019-0488-9 |
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