Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a prim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-393X/7/1/7 |
| _version_ | 1828120421351817216 |
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| author | Mariana Guerra-Maupome Mitchell V. Palmer Jodi L. McGill Randy E. Sacco |
| author_facet | Mariana Guerra-Maupome Mitchell V. Palmer Jodi L. McGill Randy E. Sacco |
| author_sort | Mariana Guerra-Maupome |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a primary viral pathogen in cases of pneumonia in young calves and plays a significant role in bovine respiratory disease complex. Importantly, naturally occurring infection of calves with bovine RSV shares many features in common with human RSV infection. Herein, we update our current understanding of RSV infection in cattle, with particular focus on similarities between the calf and human infection, and the recent reports in which the neonatal calf has been employed for the development and testing of vaccines and therapeutics which may be applied to hRSV infection in humans. |
| first_indexed | 2024-04-11T14:05:50Z |
| format | Article |
| id | doaj.art-5d5c7a066274449d8ca77de92191f6a4 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-11T14:05:50Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-5d5c7a066274449d8ca77de92191f6a42022-12-22T04:19:54ZengMDPI AGVaccines2076-393X2019-01-0171710.3390/vaccines7010007vaccines7010007Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV InfectionMariana Guerra-Maupome0Mitchell V. Palmer1Jodi L. McGill2Randy E. Sacco3Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, IA 50011, USAInfectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USADepartment of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, IA 50011, USARuminant Diseases and Immunology Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USARespiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a primary viral pathogen in cases of pneumonia in young calves and plays a significant role in bovine respiratory disease complex. Importantly, naturally occurring infection of calves with bovine RSV shares many features in common with human RSV infection. Herein, we update our current understanding of RSV infection in cattle, with particular focus on similarities between the calf and human infection, and the recent reports in which the neonatal calf has been employed for the development and testing of vaccines and therapeutics which may be applied to hRSV infection in humans.http://www.mdpi.com/2076-393X/7/1/7RSVcalf modelhumanvaccinestherapeutics |
| spellingShingle | Mariana Guerra-Maupome Mitchell V. Palmer Jodi L. McGill Randy E. Sacco Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection Vaccines RSV calf model human vaccines therapeutics |
| title | Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection |
| title_full | Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection |
| title_fullStr | Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection |
| title_full_unstemmed | Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection |
| title_short | Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection |
| title_sort | utility of the neonatal calf model for testing vaccines and intervention strategies for use against human rsv infection |
| topic | RSV calf model human vaccines therapeutics |
| url | http://www.mdpi.com/2076-393X/7/1/7 |
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