Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute
<p>Abstract</p> <p>Background</p> <p>Dedifferentiated chondrosarcomas consist of two distinguishable components: low-grade chondrosarcoma components and high-grade dedifferentiated components.</p> <p>Materials and methods</p> <p>Nine cases (4 mal...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Online Access: | http://www.josr-online.com/content/7/1/38 |
| _version_ | 1811264327978582016 |
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| author | Yokota Kazuya Sakamoto Akio Matsumoto Yoshihiro Matsuda Shuichi Harimaya Katsumi Oda Yoshinao Iwamoto Yukihide |
| author_facet | Yokota Kazuya Sakamoto Akio Matsumoto Yoshihiro Matsuda Shuichi Harimaya Katsumi Oda Yoshinao Iwamoto Yukihide |
| author_sort | Yokota Kazuya |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Dedifferentiated chondrosarcomas consist of two distinguishable components: low-grade chondrosarcoma components and high-grade dedifferentiated components.</p> <p>Materials and methods</p> <p>Nine cases (4 males, 5 females) of dedifferentiated chondrosarcoma were treated in our institute. The average age was 58.6 (range, 37–86) years. The tumor location was the long bone in 7 cases (femur, n=5; humerus, n=1; tibia, n=1) and the pelvic bone in 2 cases. The average time from appearance of symptoms to treatment was 9.4 (range, 1–40) months.</p> <p>Results and discussion</p> <p>On plain radiographs, matrix mineralization was seen in all 9 cases (100%). Bone destruction was observed in 5 of 9 cases (56%), while pathological fracture was seen in one femur case (11%). Lung metastasis was observed in all cases (initially in 5 cases; during the treatment course in 4 cases). Surgery was performed in 8 cases, with local recurrence occurring in 2 of those cases (time to recurrence, 2 and 10 months). Chemotherapy was administered in 4 cases, but did not result in significant improvement. All 9 cases died of lung metastases, with a median survival time of 10 (range, 3.4-18.8) months. The presence of initial metastasis at diagnosis was a significant unfavorable prognostic factor.</p> <p>Conclusion</p> <p>The prognosis of dedifferentiated chondrosarcoma is dismal. With the lack of convincing evidence of the benefit of chemotherapy, complete surgical excision is the initial recommended treatment.</p> |
| first_indexed | 2024-04-12T20:01:06Z |
| format | Article |
| id | doaj.art-5d5d08bfcb2f4007877a8204cbaadf0e |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-12T20:01:06Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-5d5d08bfcb2f4007877a8204cbaadf0e2022-12-22T03:18:31ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2012-12-01713810.1186/1749-799X-7-38Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single instituteYokota KazuyaSakamoto AkioMatsumoto YoshihiroMatsuda ShuichiHarimaya KatsumiOda YoshinaoIwamoto Yukihide<p>Abstract</p> <p>Background</p> <p>Dedifferentiated chondrosarcomas consist of two distinguishable components: low-grade chondrosarcoma components and high-grade dedifferentiated components.</p> <p>Materials and methods</p> <p>Nine cases (4 males, 5 females) of dedifferentiated chondrosarcoma were treated in our institute. The average age was 58.6 (range, 37–86) years. The tumor location was the long bone in 7 cases (femur, n=5; humerus, n=1; tibia, n=1) and the pelvic bone in 2 cases. The average time from appearance of symptoms to treatment was 9.4 (range, 1–40) months.</p> <p>Results and discussion</p> <p>On plain radiographs, matrix mineralization was seen in all 9 cases (100%). Bone destruction was observed in 5 of 9 cases (56%), while pathological fracture was seen in one femur case (11%). Lung metastasis was observed in all cases (initially in 5 cases; during the treatment course in 4 cases). Surgery was performed in 8 cases, with local recurrence occurring in 2 of those cases (time to recurrence, 2 and 10 months). Chemotherapy was administered in 4 cases, but did not result in significant improvement. All 9 cases died of lung metastases, with a median survival time of 10 (range, 3.4-18.8) months. The presence of initial metastasis at diagnosis was a significant unfavorable prognostic factor.</p> <p>Conclusion</p> <p>The prognosis of dedifferentiated chondrosarcoma is dismal. With the lack of convincing evidence of the benefit of chemotherapy, complete surgical excision is the initial recommended treatment.</p>http://www.josr-online.com/content/7/1/38 |
| spellingShingle | Yokota Kazuya Sakamoto Akio Matsumoto Yoshihiro Matsuda Shuichi Harimaya Katsumi Oda Yoshinao Iwamoto Yukihide Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute Journal of Orthopaedic Surgery and Research |
| title | Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute |
| title_full | Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute |
| title_fullStr | Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute |
| title_full_unstemmed | Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute |
| title_short | Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute |
| title_sort | clinical outcome for patients with dedifferentiated chondrosarcoma a report of 9 cases at a single institute |
| url | http://www.josr-online.com/content/7/1/38 |
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