P2Y2 receptor decreases blood pressure by inhibiting ENaC

P2Y2 receptor decreases blood pressure by inhibiting ENaC

Stimulating the Gq-coupled P2Y2 receptor (P2ry2) lowers blood pressure. Global knockout of P2ry2 increases blood pressure. Vascular and renal mechanisms are believed to participate in P2ry2 effects on blood pressure. To isolate the role of the kidneys in P2ry2 effects on blood pressure and to reveal...

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Bibliographic Details
Main Authors:	Antonio G. Soares, Jorge Contreras, Elena Mironova, Crystal R. Archer, James D. Stockand, Tarek Mohamed Abd El-Aziz
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2023-07-01
Series:	JCI Insight
Subjects:	Cell biology Nephrology
Online Access:	https://doi.org/10.1172/jci.insight.167704

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