Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients
Background and Objective: In obese patients, sleeve gastrectomy (SG) has shown mixed results on bile acid (BA) values. The aim of our study was to examine the potential ultra-early and early changes of the circulating total BA in relation with the changes of insulin resistance (IR) in obese patients...
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| Format: | Article |
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MDPI AG
2019-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/12/757 |
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| author | Adriana Florinela Cӑtoi Alina Elena Pârvu Aurel Mironiuc Horațiu Silaghi Ioana Delia Pop Andra Diana Andreicuț |
| author_facet | Adriana Florinela Cӑtoi Alina Elena Pârvu Aurel Mironiuc Horațiu Silaghi Ioana Delia Pop Andra Diana Andreicuț |
| author_sort | Adriana Florinela Cӑtoi |
| collection | DOAJ |
| description | Background and Objective: In obese patients, sleeve gastrectomy (SG) has shown mixed results on bile acid (BA) values. The aim of our study was to examine the potential ultra-early and early changes of the circulating total BA in relation with the changes of insulin resistance (IR) in obese patients submitted to laparoscopic SG. <i>Materials and Method</i><i>s</i><i>:</i> Twenty-four obese subjects were investigated for body mass index (BMI), total fasting BA, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and leptin before and at 7 and 30 d after SG. <i>Results:</i> After surgery, mean BMI decreased at the first (<i>p</i> < 0.001) and at the second time point (<i>p</i> < 0.001) relative to baseline. Total fasting BA values did not change significantly at 7 d (<i>p</i> = 0.938) and at 30 d (<i>p</i> = 0.289) after SG. No significant changes were found at 7 d (<i>p</i> = 0.194, <i>p</i> = 0.34) and 30 d (<i>p</i> = 0.329, <i>p</i> = 0.151) after surgery regarding fasting insulin and HOMA-IR, respectively. However, a trend of increased total fasting BA and decreased fasting insulin and HOMA- after laparoscopic SG has been found. Negative correlations between total fasting BA and insulin (r = −0.807, <i>p</i> = 0.009), HOMA-IR (r = −0.855, <i>p</i> = 0.014), and blood glucose (r = −0.761, <i>p</i> = 0.047), respectively, were observed at one month after SG. <i>Conclusion:</i> In conclusion, here, we found a lack of significant changes in total fasting BA, insulin, and HOMA-IR ultra-early and early after SG, which precluded us to consider a possible relation between the variations of BA and IR. However, the presence of the tendency for total fasting BA to increase and for insulin and HOMA-IR to decrease, as well as of the negative correlations one month after laparoscopic SG, suggest that this surgery brings about some changes that point towards the existence, and possibly towards the restoration, at least to some extent, of the link between BA and glucose metabolism. |
| first_indexed | 2024-03-12T09:29:53Z |
| format | Article |
| id | doaj.art-5d5f0473080241199d0fd5a8dcc3b970 |
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| language | English |
| last_indexed | 2024-03-12T09:29:53Z |
| publishDate | 2019-11-01 |
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| spelling | doaj.art-5d5f0473080241199d0fd5a8dcc3b9702023-09-02T13:55:51ZengMDPI AGMedicina1010-660X2019-11-01551275710.3390/medicina55120757medicina55120757Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese PatientsAdriana Florinela Cӑtoi0Alina Elena Pârvu1Aurel MironiucHorațiu SilaghiIoana Delia Pop2Andra Diana Andreicuț3Department of Pathophysiology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Pathophysiology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Exact Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, RomaniaDepartment of Pathophysiology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaBackground and Objective: In obese patients, sleeve gastrectomy (SG) has shown mixed results on bile acid (BA) values. The aim of our study was to examine the potential ultra-early and early changes of the circulating total BA in relation with the changes of insulin resistance (IR) in obese patients submitted to laparoscopic SG. <i>Materials and Method</i><i>s</i><i>:</i> Twenty-four obese subjects were investigated for body mass index (BMI), total fasting BA, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and leptin before and at 7 and 30 d after SG. <i>Results:</i> After surgery, mean BMI decreased at the first (<i>p</i> < 0.001) and at the second time point (<i>p</i> < 0.001) relative to baseline. Total fasting BA values did not change significantly at 7 d (<i>p</i> = 0.938) and at 30 d (<i>p</i> = 0.289) after SG. No significant changes were found at 7 d (<i>p</i> = 0.194, <i>p</i> = 0.34) and 30 d (<i>p</i> = 0.329, <i>p</i> = 0.151) after surgery regarding fasting insulin and HOMA-IR, respectively. However, a trend of increased total fasting BA and decreased fasting insulin and HOMA- after laparoscopic SG has been found. Negative correlations between total fasting BA and insulin (r = −0.807, <i>p</i> = 0.009), HOMA-IR (r = −0.855, <i>p</i> = 0.014), and blood glucose (r = −0.761, <i>p</i> = 0.047), respectively, were observed at one month after SG. <i>Conclusion:</i> In conclusion, here, we found a lack of significant changes in total fasting BA, insulin, and HOMA-IR ultra-early and early after SG, which precluded us to consider a possible relation between the variations of BA and IR. However, the presence of the tendency for total fasting BA to increase and for insulin and HOMA-IR to decrease, as well as of the negative correlations one month after laparoscopic SG, suggest that this surgery brings about some changes that point towards the existence, and possibly towards the restoration, at least to some extent, of the link between BA and glucose metabolism.https://www.mdpi.com/1010-660X/55/12/757severe obesitybile acidsinsulin resistancesleeve gastrectomy |
| spellingShingle | Adriana Florinela Cӑtoi Alina Elena Pârvu Aurel Mironiuc Horațiu Silaghi Ioana Delia Pop Andra Diana Andreicuț Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients Medicina severe obesity bile acids insulin resistance sleeve gastrectomy |
| title | Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients |
| title_full | Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients |
| title_fullStr | Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients |
| title_full_unstemmed | Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients |
| title_short | Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients |
| title_sort | ultra early and early changes in bile acids and insulin after sleeve gastrectomy among obese patients |
| topic | severe obesity bile acids insulin resistance sleeve gastrectomy |
| url | https://www.mdpi.com/1010-660X/55/12/757 |
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