Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial
Introduction Although music therapy (MT) has been found to reduce anxiety in patients with cancer and delay tumour progression to some extent, its mechanism of action has not been determined. MT may reduce anxiety by reducing the concentrations of proinflammatory cytokines. The present study was des...
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| Format: | Article |
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BMJ Publishing Group
2023-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/5/e067360.full |
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| author | Hao Liu Ping Zhou Ling Xu Chenbing Sun Shuliu Sang Yunzhe Tang Xiaodie Niu Hwa-Seung Yoo Yabin Gong |
| author_facet | Hao Liu Ping Zhou Ling Xu Chenbing Sun Shuliu Sang Yunzhe Tang Xiaodie Niu Hwa-Seung Yoo Yabin Gong |
| author_sort | Hao Liu |
| collection | DOAJ |
| description | Introduction Although music therapy (MT) has been found to reduce anxiety in patients with cancer and delay tumour progression to some extent, its mechanism of action has not been determined. MT may reduce anxiety by reducing the concentrations of proinflammatory cytokines. The present study was designed to evaluate the effects of MT on anxiety and cytokine levels in patients with cancer.Methods and analysis This randomised, open, single-centre parallel-controlled trial will randomise 60 patients with malignant tumours who meet the inclusion criteria in a 1:1 ratio to either an MT group or a non-MT (NMT) group. Patients in the MT group will receive emotional nursing care and individualised receptive MT for 1 week, whereas patients in the NMT group will receive emotional nursing care alone. Primary outcomes will include scores on the State-Trait Anxiety Inventory, Distress Thermometer and Hamilton Anxiety Scale. Secondary outcomes will include scores on the Quality of Life Questionnaire C30, serum concentrations of the cytokines interleukin (IL)-1β, tumour necrosis factor-α, IL-2R, IL-4, IL-6, IL-8 and IL-10, serum concentrations of the neurotransmitters 5-hydroxytryptamine, dopamine, norepinephrine, adrenocorticotropic hormone and γ-aminobutyric acid, and determination of gut microbiota populations.Ethics and dissemination On 5 August 2020, the study protocol was approved by the Research Ethics Committee of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine of the Shanghai University of Traditional Chinese Medicine. The findings of this study will be published in peer-reviewed publications and presented at appropriate conferences.Trial registration number CTR2000035244. |
| first_indexed | 2024-03-13T08:48:03Z |
| format | Article |
| id | doaj.art-5d626a6e31f547aaa518649007b6868b |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-13T08:48:03Z |
| publishDate | 2023-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-5d626a6e31f547aaa518649007b6868b2023-05-29T20:30:06ZengBMJ Publishing GroupBMJ Open2044-60552023-05-0113510.1136/bmjopen-2022-067360Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trialHao Liu0Ping Zhou1Ling Xu2Chenbing Sun3Shuliu Sang4Yunzhe Tang5Xiaodie Niu6Hwa-Seung Yoo7Yabin Gong82State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, Shaanxi Province, China9 National Institute of Biological Sciences Beijing, Beijing, ChinaSchool of Elderly Care Services and management, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, ChinaDepartment of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Integrative Oncology, East West Cancer Center, Seoul Korea Medicine Hospital, Seoul, Korea (the Republic of)Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaIntroduction Although music therapy (MT) has been found to reduce anxiety in patients with cancer and delay tumour progression to some extent, its mechanism of action has not been determined. MT may reduce anxiety by reducing the concentrations of proinflammatory cytokines. The present study was designed to evaluate the effects of MT on anxiety and cytokine levels in patients with cancer.Methods and analysis This randomised, open, single-centre parallel-controlled trial will randomise 60 patients with malignant tumours who meet the inclusion criteria in a 1:1 ratio to either an MT group or a non-MT (NMT) group. Patients in the MT group will receive emotional nursing care and individualised receptive MT for 1 week, whereas patients in the NMT group will receive emotional nursing care alone. Primary outcomes will include scores on the State-Trait Anxiety Inventory, Distress Thermometer and Hamilton Anxiety Scale. Secondary outcomes will include scores on the Quality of Life Questionnaire C30, serum concentrations of the cytokines interleukin (IL)-1β, tumour necrosis factor-α, IL-2R, IL-4, IL-6, IL-8 and IL-10, serum concentrations of the neurotransmitters 5-hydroxytryptamine, dopamine, norepinephrine, adrenocorticotropic hormone and γ-aminobutyric acid, and determination of gut microbiota populations.Ethics and dissemination On 5 August 2020, the study protocol was approved by the Research Ethics Committee of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine of the Shanghai University of Traditional Chinese Medicine. The findings of this study will be published in peer-reviewed publications and presented at appropriate conferences.Trial registration number CTR2000035244.https://bmjopen.bmj.com/content/13/5/e067360.full |
| spellingShingle | Hao Liu Ping Zhou Ling Xu Chenbing Sun Shuliu Sang Yunzhe Tang Xiaodie Niu Hwa-Seung Yoo Yabin Gong Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial BMJ Open |
| title | Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial |
| title_full | Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial |
| title_fullStr | Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial |
| title_full_unstemmed | Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial |
| title_short | Effects of music therapy on anxiety in patients with cancer: study protocol of a randomised controlled trial |
| title_sort | effects of music therapy on anxiety in patients with cancer study protocol of a randomised controlled trial |
| url | https://bmjopen.bmj.com/content/13/5/e067360.full |
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