Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity
Bacterial colonization occurs on all biological and artificial surfaces in the oral cavity. The formation of multicellular biofilms or settlement of misallocated species can cause caries (diet‐depending acidification), periodontal diseases, peri‐implantitis, or denture‐associated stomatitis. Inhibit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-07-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202300031 |
| _version_ | 1797785513061515264 |
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| author | Ralf Helbig Christian Hannig Sabine Basche Janis Ortgies Matthias Hannig Torsten Sterzenbach |
| author_facet | Ralf Helbig Christian Hannig Sabine Basche Janis Ortgies Matthias Hannig Torsten Sterzenbach |
| author_sort | Ralf Helbig |
| collection | DOAJ |
| description | Bacterial colonization occurs on all biological and artificial surfaces in the oral cavity. The formation of multicellular biofilms or settlement of misallocated species can cause caries (diet‐depending acidification), periodontal diseases, peri‐implantitis, or denture‐associated stomatitis. Inhibition or delay of initial adhesion should strongly reduce dental interventions. However, no strategy is found to mildly manage bacterial colonization in this complex physiological environment, that is, without toxic, antibacterial, or antiseptic approaches. It is shown in a previous study that micro‐ and submicrometer surface topographies, which can effectively control initial bacterial adhesion in other application areas, do not have any significant impact within the oral cavity. Herein, a simple approach is presented to reduce initial microbial surface colonization by plain biphasic textures with defined combinations of hydrophobic and hydrophilic phases (SiO2, NH2, CH2, CH3, F3). A significant reduction of microbial adhesion on textures in the nano‐ and microscale (150 nm and 2.4 μm) compared to respective monophasic substrates is observed. This might be a new design principle for dental materials, to inhibit microbial colonization in critical scenarios, at least for shorter time scales (<24 h). |
| first_indexed | 2024-03-13T00:55:08Z |
| format | Article |
| id | doaj.art-5d645b150052481eacb79b2996a59375 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-13T00:55:08Z |
| publishDate | 2023-07-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-5d645b150052481eacb79b2996a593752023-07-07T02:00:41ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-07-0137n/an/a10.1002/anbr.202300031Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral CavityRalf Helbig0Christian Hannig1Sabine Basche2Janis Ortgies3Matthias Hannig4Torsten Sterzenbach5Max Bergmann Center of Biomaterials Leibniz Institute of Polymer Research Hohe Straße 6 01069 Dresden GermanyClinic of Operative and Pediatric Density Medical Faculty Carl Gustav Carus Technische Universität Dresden Fetscherstraße 74 01307 Dresden GermanyClinic of Operative and Pediatric Density Medical Faculty Carl Gustav Carus Technische Universität Dresden Fetscherstraße 74 01307 Dresden GermanyClinic of Operative Dentistry Periodontology and Preventive Dentistry University Hospital Saarland University 66421 Homburg GermanyClinic of Operative Dentistry Periodontology and Preventive Dentistry University Hospital Saarland University 66421 Homburg GermanyClinic of Operative and Pediatric Density Medical Faculty Carl Gustav Carus Technische Universität Dresden Fetscherstraße 74 01307 Dresden GermanyBacterial colonization occurs on all biological and artificial surfaces in the oral cavity. The formation of multicellular biofilms or settlement of misallocated species can cause caries (diet‐depending acidification), periodontal diseases, peri‐implantitis, or denture‐associated stomatitis. Inhibition or delay of initial adhesion should strongly reduce dental interventions. However, no strategy is found to mildly manage bacterial colonization in this complex physiological environment, that is, without toxic, antibacterial, or antiseptic approaches. It is shown in a previous study that micro‐ and submicrometer surface topographies, which can effectively control initial bacterial adhesion in other application areas, do not have any significant impact within the oral cavity. Herein, a simple approach is presented to reduce initial microbial surface colonization by plain biphasic textures with defined combinations of hydrophobic and hydrophilic phases (SiO2, NH2, CH2, CH3, F3). A significant reduction of microbial adhesion on textures in the nano‐ and microscale (150 nm and 2.4 μm) compared to respective monophasic substrates is observed. This might be a new design principle for dental materials, to inhibit microbial colonization in critical scenarios, at least for shorter time scales (<24 h).https://doi.org/10.1002/anbr.202300031bioadhesionbiphasic texturesdentistrymicrobiotaoral cavities |
| spellingShingle | Ralf Helbig Christian Hannig Sabine Basche Janis Ortgies Matthias Hannig Torsten Sterzenbach Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity Advanced NanoBiomed Research bioadhesion biphasic textures dentistry microbiota oral cavities |
| title | Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity |
| title_full | Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity |
| title_fullStr | Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity |
| title_full_unstemmed | Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity |
| title_short | Biphasic Textures Reducing Bacterial Surface Colonization in the Human Oral Cavity |
| title_sort | biphasic textures reducing bacterial surface colonization in the human oral cavity |
| topic | bioadhesion biphasic textures dentistry microbiota oral cavities |
| url | https://doi.org/10.1002/anbr.202300031 |
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