Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML

Investigation of the mechanism of USP28-mediated IFITM3 elevation in BCR-ABL-dependent imatinib resistance in CML

Due to resistance and BCR-ABLT315I-mutated, CML remains a clinical challenge. It needs new potential therapeutic targets to overcome CML resistance related to BCR-ABL. Our research revealed that the deubiquitinating enzyme USP28 was highly expressed in BCR-ABL-dependent CML patients. Similarly, a hi...

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Bibliographic Details
Main Authors: Zilin Li, Yiling Xi, Linglan Tu, Xu Zhang, Yue Huang, Huizong Nie, Cheng Peng, Haohuan Chai, Shenxin Zeng, Xiaoliang Zheng, Liyan Cheng
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CML
USP28
BCR-ABL
IFITM3
Drug resistance
Protacs
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001963

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