The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients.
Background and rationale: Coronavirus disease 2019 (COVID-19) infection is a respiratory tract infection because of a novel coronavirus. The clinical picture ranges from asymptomatic to severe manifestations mandating intensive care and respiratory support. We aimed to assess the serum level of iron...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2023-05-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_281985_dfd14d71555470318c5977de8d7e144e.pdf |
| _version_ | 1797827837032398848 |
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| author | Mira Atef Hala Ramadan Hanan Abdel-Haleem Rasha Abdalaziz Aya Al-sharif Reem El-Korashy Youssef Soliman Sabah Hussein Ahmed Hashem Manal Kamal Mona Abdullatif Mohammed Abdel Razik Ahmed Ramadan |
| author_facet | Mira Atef Hala Ramadan Hanan Abdel-Haleem Rasha Abdalaziz Aya Al-sharif Reem El-Korashy Youssef Soliman Sabah Hussein Ahmed Hashem Manal Kamal Mona Abdullatif Mohammed Abdel Razik Ahmed Ramadan |
| author_sort | Mira Atef |
| collection | DOAJ |
| description | Background and rationale: Coronavirus disease 2019 (COVID-19) infection is a respiratory tract infection because of a novel coronavirus. The clinical picture ranges from asymptomatic to severe manifestations mandating intensive care and respiratory support. We aimed to assess the serum level of iron, total iron binding capacity (TIBC), and transferrin saturation in COVID-19 patients and their relation to disease severity and outcome. Methodology: This observational cross-sectional analytical study was conducted on 100 confirmed cases of COVID-19 who were admitted to Kasr Al-Ainy hospitals between June and December 2020.Serum levels of iron, total iron binding capacity (TIBC), and transferrin saturation were measured for all study populations. Result: One hundred patients were involved in this research, 51males and 49 females, with a mean age of 51±14.9years. Regarding the disease severity,53% were moderate cases, 34% were mild, and 13% were severe cases. Fifty-two (54.2%) patients showed normal serum levels of iron, 38 patients (39.6%) showed high serum levels of iron, and 6 patients (6.3%) showed low serum levels of iron. The mean ±SD values of iron, TIBC, and transferrin saturation were 163.1±105 mcg/dL, 366 ± 162.6 mcg/dL, 44.4 ± 20.2 %, respectively. Iron, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association as regards either COVID-19 severity or mortality. Mortality and deterioration were detected in 31.7% out of 60 patients with COVID-19. The results showed that obese patients showed a higher percentage of severe COVID-19,which was statistically significant (p < /em>=0.037).There was a statistically significant higher mortality rate in patients with severe COVID-19 (p < /em>=0.000).High mortality was observed significantly in patients with diabetes mellitus (p < /em>=0.041).Iron levels, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association regarding either COVID-19 severity or mortality. Conclusion: In our study, COVID-19 severity was not related to iron metabolism but was affected by obesity and diabetes mellitus. COVID-19 mortality was significantly associated with diabetes. |
| first_indexed | 2024-04-09T12:54:45Z |
| format | Article |
| id | doaj.art-5d6e72913ca6436ba7cbbf5e953e3444 |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-09T12:54:45Z |
| publishDate | 2023-05-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-5d6e72913ca6436ba7cbbf5e953e34442023-05-13T20:41:23ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402023-05-014239340010.21608/mid.2023.184087.1439281985The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients.Mira Atef0Hala Ramadan1Hanan Abdel-Haleem2Rasha Abdalaziz3Aya Al-sharif4Reem El-Korashy5Youssef Soliman6Sabah Hussein7Ahmed Hashem8Manal Kamal9Mona Abdullatif10Mohammed Abdel Razik11Ahmed Ramadan12Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.Internal Medicine department, Faculty of Medicine, Cairo University, Egypt.Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University.Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.Pulmonary Medicine department, Faculty of Medicine, Cairo University, Egypt.National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University,Egypt.Clinical and Chemical Pathology department, Faculty of Medicine, Cairo University, Egypt.Public health and Community Medicine department, faculty of medicine, Cairo University, Egypt.Hepatogastroentrology and Endemic Medicine department, Faculty of Medicine, Cairo University, Egypt.Background and rationale: Coronavirus disease 2019 (COVID-19) infection is a respiratory tract infection because of a novel coronavirus. The clinical picture ranges from asymptomatic to severe manifestations mandating intensive care and respiratory support. We aimed to assess the serum level of iron, total iron binding capacity (TIBC), and transferrin saturation in COVID-19 patients and their relation to disease severity and outcome. Methodology: This observational cross-sectional analytical study was conducted on 100 confirmed cases of COVID-19 who were admitted to Kasr Al-Ainy hospitals between June and December 2020.Serum levels of iron, total iron binding capacity (TIBC), and transferrin saturation were measured for all study populations. Result: One hundred patients were involved in this research, 51males and 49 females, with a mean age of 51±14.9years. Regarding the disease severity,53% were moderate cases, 34% were mild, and 13% were severe cases. Fifty-two (54.2%) patients showed normal serum levels of iron, 38 patients (39.6%) showed high serum levels of iron, and 6 patients (6.3%) showed low serum levels of iron. The mean ±SD values of iron, TIBC, and transferrin saturation were 163.1±105 mcg/dL, 366 ± 162.6 mcg/dL, 44.4 ± 20.2 %, respectively. Iron, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association as regards either COVID-19 severity or mortality. Mortality and deterioration were detected in 31.7% out of 60 patients with COVID-19. The results showed that obese patients showed a higher percentage of severe COVID-19,which was statistically significant (p < /em>=0.037).There was a statistically significant higher mortality rate in patients with severe COVID-19 (p < /em>=0.000).High mortality was observed significantly in patients with diabetes mellitus (p < /em>=0.041).Iron levels, total iron binding capacity (TIBC) levels and transferrin saturation did not show a significant association regarding either COVID-19 severity or mortality. Conclusion: In our study, COVID-19 severity was not related to iron metabolism but was affected by obesity and diabetes mellitus. COVID-19 mortality was significantly associated with diabetes.https://mid.journals.ekb.eg/article_281985_dfd14d71555470318c5977de8d7e144e.pdfirontibccovid-19 patientsdisease severity |
| spellingShingle | Mira Atef Hala Ramadan Hanan Abdel-Haleem Rasha Abdalaziz Aya Al-sharif Reem El-Korashy Youssef Soliman Sabah Hussein Ahmed Hashem Manal Kamal Mona Abdullatif Mohammed Abdel Razik Ahmed Ramadan The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. Microbes and Infectious Diseases iron tibc covid-19 patients disease severity |
| title | The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. |
| title_full | The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. |
| title_fullStr | The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. |
| title_full_unstemmed | The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. |
| title_short | The COVID-19 and iron-repertoire in an observational cross-sectional analytical study of Egyptian patients. |
| title_sort | covid 19 and iron repertoire in an observational cross sectional analytical study of egyptian patients |
| topic | iron tibc covid-19 patients disease severity |
| url | https://mid.journals.ekb.eg/article_281985_dfd14d71555470318c5977de8d7e144e.pdf |
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