Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
Objective: To study the effects of different psychotropic drugs on sleep architecture and sleep-related disorders. Material and Methods: In this retrospective review of 405 consecutive de-identified diagnostic polysomnograms performed at a sleep laboratory from 2007 until 2011, we grouped 34...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2021-10-01
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| Series: | Sleep Science |
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| Online Access: | https://www.sleepscience.org.br/details/2822/en-US/comparative-effects-of-psychotropic-medications-on-sleep-architecture--a-retrospective-review-of-diagnostic-polysomnography-sleep-parameters |
| _version_ | 1797330911826542592 |
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| author | Elias Ghossoub Luna Geagea Firas Kobeissy Farid Talih |
| author_facet | Elias Ghossoub Luna Geagea Firas Kobeissy Farid Talih |
| author_sort | Elias Ghossoub |
| collection | DOAJ |
| description | Objective: To study the effects of different psychotropic drugs on sleep architecture and sleep-related disorders.
Material and Methods: In this retrospective review of 405 consecutive de-identified diagnostic polysomnograms performed at a sleep laboratory from 2007 until 2011, we grouped 347 polysomnograms into five categories: controls, antidepressants (AD), antidepressants + anticonvulsants (ADAC), antidepressants + antipsychotics (ADAP), antidepressants + anticonvulsants + antipsychotics (ADACP). We conducted pairwise comparisons for demographic characteristics, medical history, specific psychotropic medication uses and sleep architecture variables, and adjusted for multiple testing. We used logistic regression to determine the odds ratio of having elevated apnea-hypopnea index (AHI) and periodic limb movement index (PLMI) within each group as compared to controls.
Results: Compared to controls, all groups had a significantly higher prevalence of benzodiazepines and trazodone use. AD and ADACP had significantly longer REM latency and lower REM percentage of total sleep time compared to controls. ADAP had a significantly lower AHI compared to controls, but that association was lost in the regression model. AD was associated with a higher PLMI compared to controls.
Conclusion: Psychotropic polypharmacy does not seem to be associated with significantly deleterious effects on sleep architecture. Adjunct anticonvulsants or antipsychotics to antidepressants may protect against periodic limb movement disorder. |
| first_indexed | 2024-03-08T07:27:05Z |
| format | Article |
| id | doaj.art-5d6fd6ebd64442bb86a2564f9523cdc7 |
| institution | Directory Open Access Journal |
| issn | 1984-0659 1984-0063 |
| language | English |
| last_indexed | 2024-03-08T07:27:05Z |
| publishDate | 2021-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj.art-5d6fd6ebd64442bb86a2564f9523cdc72024-02-02T21:36:22ZengThieme Revinter Publicações Ltda.Sleep Science1984-06591984-00632021-10-01143236244000810.5935/1984-0063.20200071Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parametersElias Ghossoub0Luna Geagea1Firas Kobeissy2Farid Talih3American University of Beirut, Psychiatry, Beirut, Lebanon.American University of Beirut, Psychiatry, Beirut, Lebanon.American University of Beirut, Biochemistry and Molecular Genetics, Beirut, Beriut, Lebanon.American University of Beirut, Psychiatry, Beirut, Lebanon.Objective: To study the effects of different psychotropic drugs on sleep architecture and sleep-related disorders. Material and Methods: In this retrospective review of 405 consecutive de-identified diagnostic polysomnograms performed at a sleep laboratory from 2007 until 2011, we grouped 347 polysomnograms into five categories: controls, antidepressants (AD), antidepressants + anticonvulsants (ADAC), antidepressants + antipsychotics (ADAP), antidepressants + anticonvulsants + antipsychotics (ADACP). We conducted pairwise comparisons for demographic characteristics, medical history, specific psychotropic medication uses and sleep architecture variables, and adjusted for multiple testing. We used logistic regression to determine the odds ratio of having elevated apnea-hypopnea index (AHI) and periodic limb movement index (PLMI) within each group as compared to controls. Results: Compared to controls, all groups had a significantly higher prevalence of benzodiazepines and trazodone use. AD and ADACP had significantly longer REM latency and lower REM percentage of total sleep time compared to controls. ADAP had a significantly lower AHI compared to controls, but that association was lost in the regression model. AD was associated with a higher PLMI compared to controls. Conclusion: Psychotropic polypharmacy does not seem to be associated with significantly deleterious effects on sleep architecture. Adjunct anticonvulsants or antipsychotics to antidepressants may protect against periodic limb movement disorder.https://www.sleepscience.org.br/details/2822/en-US/comparative-effects-of-psychotropic-medications-on-sleep-architecture--a-retrospective-review-of-diagnostic-polysomnography-sleep-parameterssleep wake disordersnocturnal myoclonus syndromeperiodic limb movements disordersleep apnea |
| spellingShingle | Elias Ghossoub Luna Geagea Firas Kobeissy Farid Talih Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters Sleep Science sleep wake disorders nocturnal myoclonus syndrome periodic limb movements disorder sleep apnea |
| title | Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters |
| title_full | Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters |
| title_fullStr | Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters |
| title_full_unstemmed | Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters |
| title_short | Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters |
| title_sort | comparative effects of psychotropic medications on sleep architecture a retrospective review of diagnostic polysomnography sleep parameters |
| topic | sleep wake disorders nocturnal myoclonus syndrome periodic limb movements disorder sleep apnea |
| url | https://www.sleepscience.org.br/details/2822/en-US/comparative-effects-of-psychotropic-medications-on-sleep-architecture--a-retrospective-review-of-diagnostic-polysomnography-sleep-parameters |
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