Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis

Mass vaccination against COVID-19 is essential to control the pandemic. COVID-19 vaccines are now recommended during pregnancy to prevent adverse outcomes. With this review, we aimed to evaluate the evidence in the literature regarding the uptake of COVID-19 vaccinations among pregnant women. A comp...

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Main Authors: Petros Galanis, Irene Vraka, Olga Siskou, Olympia Konstantakopoulou, Aglaia Katsiroumpa, Daphne Kaitelidou
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/10/5/766
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author Petros Galanis
Irene Vraka
Olga Siskou
Olympia Konstantakopoulou
Aglaia Katsiroumpa
Daphne Kaitelidou
author_facet Petros Galanis
Irene Vraka
Olga Siskou
Olympia Konstantakopoulou
Aglaia Katsiroumpa
Daphne Kaitelidou
author_sort Petros Galanis
collection DOAJ
description Mass vaccination against COVID-19 is essential to control the pandemic. COVID-19 vaccines are now recommended during pregnancy to prevent adverse outcomes. With this review, we aimed to evaluate the evidence in the literature regarding the uptake of COVID-19 vaccinations among pregnant women. A comprehensive search was performed in PubMed, Medline, Scopus, ProQuest, Web of Science, CINAHL, and medRxiv from inception to 23 March 2022. We performed a meta-analysis to estimate the overall proportion of pregnant women vaccinated against COVID-19. We found 11 studies including 703,004 pregnant women. The overall proportion of pregnant women vaccinated against COVID-19 was 27.5% (95% CI: 18.8–37.0%). Predictors of COVID-19 vaccination uptake were older age, ethnicity, race, trust in COVID-19 vaccines, and fear of COVID-19 during pregnancy. Mistrust in the government, diagnosis of COVID-19 during pregnancy, and fears about the safety and side effects of COVID-19 vaccines were reasons for declining vaccination. The global COVID-19 vaccination prevalence in pregnant women is low. A large gap exists in the literature on the factors influencing the decision of pregnant women to be vaccinated against COVID-19. Targeted information campaigns are essential to increase vaccine literacy among pregnant women.
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spelling doaj.art-5d6fe0c5c5d0426ab3b38b311b43b5c72023-11-23T13:26:52ZengMDPI AGVaccines2076-393X2022-05-0110576610.3390/vaccines10050766Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-AnalysisPetros Galanis0Irene Vraka1Olga Siskou2Olympia Konstantakopoulou3Aglaia Katsiroumpa4Daphne Kaitelidou5Clinical Epidemiology Laboratory, Faculty of Nursing, National and Kapodistrian University of Athens, 15773 Athens, GreeceDepartment of Radiology, P. & A. Kyriakou Children’s Hospital, 15773 Athens, GreeceCenter for Health Services Management and Evaluation, Faculty of Nursing, National and Kapodistrian University of Athens, 15773 Athens, GreeceCenter for Health Services Management and Evaluation, Faculty of Nursing, National and Kapodistrian University of Athens, 15773 Athens, GreeceClinical Epidemiology Laboratory, Faculty of Nursing, National and Kapodistrian University of Athens, 15773 Athens, GreeceCenter for Health Services Management and Evaluation, Faculty of Nursing, National and Kapodistrian University of Athens, 15773 Athens, GreeceMass vaccination against COVID-19 is essential to control the pandemic. COVID-19 vaccines are now recommended during pregnancy to prevent adverse outcomes. With this review, we aimed to evaluate the evidence in the literature regarding the uptake of COVID-19 vaccinations among pregnant women. A comprehensive search was performed in PubMed, Medline, Scopus, ProQuest, Web of Science, CINAHL, and medRxiv from inception to 23 March 2022. We performed a meta-analysis to estimate the overall proportion of pregnant women vaccinated against COVID-19. We found 11 studies including 703,004 pregnant women. The overall proportion of pregnant women vaccinated against COVID-19 was 27.5% (95% CI: 18.8–37.0%). Predictors of COVID-19 vaccination uptake were older age, ethnicity, race, trust in COVID-19 vaccines, and fear of COVID-19 during pregnancy. Mistrust in the government, diagnosis of COVID-19 during pregnancy, and fears about the safety and side effects of COVID-19 vaccines were reasons for declining vaccination. The global COVID-19 vaccination prevalence in pregnant women is low. A large gap exists in the literature on the factors influencing the decision of pregnant women to be vaccinated against COVID-19. Targeted information campaigns are essential to increase vaccine literacy among pregnant women.https://www.mdpi.com/2076-393X/10/5/766pregnant womenCOVID-19vaccinationuptakepredictors
spellingShingle Petros Galanis
Irene Vraka
Olga Siskou
Olympia Konstantakopoulou
Aglaia Katsiroumpa
Daphne Kaitelidou
Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis
Vaccines
pregnant women
COVID-19
vaccination
uptake
predictors
title Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis
title_full Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis
title_fullStr Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis
title_full_unstemmed Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis
title_short Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis
title_sort uptake of covid 19 vaccines among pregnant women a systematic review and meta analysis
topic pregnant women
COVID-19
vaccination
uptake
predictors
url https://www.mdpi.com/2076-393X/10/5/766
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