Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests
Humans are exposed to micro and nanoplastics (MNPLs) through inhalation, ingestion and, to a lesser extent, dermal contact. In recent years, new insights indicate the potential of MNPLs to cause damages to human health. Particle toxicity can include oxidative stress, inflammatory lesions, and then i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Toxicology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2021.752140/full |
| _version_ | 1819124608339542016 |
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| author | Marta Llorca Marinella Farré |
| author_facet | Marta Llorca Marinella Farré |
| author_sort | Marta Llorca |
| collection | DOAJ |
| description | Humans are exposed to micro and nanoplastics (MNPLs) through inhalation, ingestion and, to a lesser extent, dermal contact. In recent years, new insights indicate the potential of MNPLs to cause damages to human health. Particle toxicity can include oxidative stress, inflammatory lesions, and then increased internalization or translocation through tissues. On the other hand, plastic additives are used in plastic particles, once internalized, can release toxic substances. It is noteworthy that the potential effects of MNPLs encompass a wide range of polymers and chemical additives, showing various physicochemical and toxicological properties, and the size, shape and surface properties are other variables influencing their effects. In spite of the research carried out recently, MNPLs research is in its early stages, and further investigation is required. In this review article, the knowledge of human exposure routes and the recent results on the toxicological effects of MNPLs in human health are presented and discussed. Finally, the current limitations and the main gaps in the body of knowledge are summarised. |
| first_indexed | 2024-12-22T07:26:57Z |
| format | Article |
| id | doaj.art-5d708bd2ede24d1e92411b30e45ea1ea |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-12-22T07:26:57Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-5d708bd2ede24d1e92411b30e45ea1ea2022-12-21T18:34:07ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802021-09-01310.3389/ftox.2021.752140752140Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro TestsMarta LlorcaMarinella FarréHumans are exposed to micro and nanoplastics (MNPLs) through inhalation, ingestion and, to a lesser extent, dermal contact. In recent years, new insights indicate the potential of MNPLs to cause damages to human health. Particle toxicity can include oxidative stress, inflammatory lesions, and then increased internalization or translocation through tissues. On the other hand, plastic additives are used in plastic particles, once internalized, can release toxic substances. It is noteworthy that the potential effects of MNPLs encompass a wide range of polymers and chemical additives, showing various physicochemical and toxicological properties, and the size, shape and surface properties are other variables influencing their effects. In spite of the research carried out recently, MNPLs research is in its early stages, and further investigation is required. In this review article, the knowledge of human exposure routes and the recent results on the toxicological effects of MNPLs in human health are presented and discussed. Finally, the current limitations and the main gaps in the body of knowledge are summarised.https://www.frontiersin.org/articles/10.3389/ftox.2021.752140/fullnanoplasticsmicroplasticshuman heathtoxicologyroutes of exposure |
| spellingShingle | Marta Llorca Marinella Farré Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests Frontiers in Toxicology nanoplastics microplastics human heath toxicology routes of exposure |
| title | Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests |
| title_full | Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests |
| title_fullStr | Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests |
| title_full_unstemmed | Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests |
| title_short | Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests |
| title_sort | current insights into potential effects of micro nanoplastics on human health by in vitro tests |
| topic | nanoplastics microplastics human heath toxicology routes of exposure |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2021.752140/full |
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