Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma
BackgroundStaging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated combined molecular markers to predict prognosis.Patients and methods890 tumor tissue samples were obtained from patients who underwent surgery...
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1249172/full |
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| author | Verena Maria Raters Florian Gebauer Heike Löser Wolfgang Schröder Hans Anton Schlösser Hans Fuchs Christiane Bruns Alexander Quaas Thomas Zander |
| author_facet | Verena Maria Raters Florian Gebauer Heike Löser Wolfgang Schröder Hans Anton Schlösser Hans Fuchs Christiane Bruns Alexander Quaas Thomas Zander |
| author_sort | Verena Maria Raters |
| collection | DOAJ |
| description | BackgroundStaging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated combined molecular markers to predict prognosis.Patients and methods890 tumor tissue samples were obtained from patients who underwent surgery for esophageal adenocarcinoma with curative intent. These were stained by tissue micro array for 48 markers which are associated with tumorigenesis and correlated with clinical data (TNM-staging, overall survival) by multivariate Cox regression.ResultsTwo markers (preserved Y chromosome and high grade of (CD3+) T-cell infiltration) were found to be significantly and independently associated with better overall survival. We formed a score (called CY score) from the two markers. The more markers are positive and thus the higher the score (ranging from 0 to 2), the better the overall survival, independently of UICC. Moreover, we developed a combination score of the UICC and CY score based on cluster analysis. Patients with a UICC stage of III with the presence of both traits (CY=2) can be assigned to a better prognosis group (group II), whereas patients with a UICC stage of I without both traits (CY=0) must be assigned to a worse prognosis group (group II). Therefore, patients in stage I with adverse molecular signature might benefit of multimodal therapy.ConclusionIn summary, the CY score adds prognostic information to the UICC stage based on tumor biology in esophageal adenocarcinoma and warrants further evaluations in independent clinical cohorts. |
| first_indexed | 2024-03-11T01:58:52Z |
| format | Article |
| id | doaj.art-5d73185de5b04e4386febeaf118e9865 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T01:58:52Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5d73185de5b04e4386febeaf118e98652023-11-18T12:24:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-11-011310.3389/fonc.2023.12491721249172Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinomaVerena Maria Raters0Florian Gebauer1Heike Löser2Wolfgang Schröder3Hans Anton Schlösser4Hans Fuchs5Christiane Bruns6Alexander Quaas7Thomas Zander8Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyInstitute of Pathology, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyDepartment of General, Visceral and Cancer Surgery, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyInstitute of Pathology, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyDepartment I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, GermanyBackgroundStaging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity. Therefore, we evaluated combined molecular markers to predict prognosis.Patients and methods890 tumor tissue samples were obtained from patients who underwent surgery for esophageal adenocarcinoma with curative intent. These were stained by tissue micro array for 48 markers which are associated with tumorigenesis and correlated with clinical data (TNM-staging, overall survival) by multivariate Cox regression.ResultsTwo markers (preserved Y chromosome and high grade of (CD3+) T-cell infiltration) were found to be significantly and independently associated with better overall survival. We formed a score (called CY score) from the two markers. The more markers are positive and thus the higher the score (ranging from 0 to 2), the better the overall survival, independently of UICC. Moreover, we developed a combination score of the UICC and CY score based on cluster analysis. Patients with a UICC stage of III with the presence of both traits (CY=2) can be assigned to a better prognosis group (group II), whereas patients with a UICC stage of I without both traits (CY=0) must be assigned to a worse prognosis group (group II). Therefore, patients in stage I with adverse molecular signature might benefit of multimodal therapy.ConclusionIn summary, the CY score adds prognostic information to the UICC stage based on tumor biology in esophageal adenocarcinoma and warrants further evaluations in independent clinical cohorts.https://www.frontiersin.org/articles/10.3389/fonc.2023.1249172/fullesophageal adenocarcinomaY chromosome lossCD3 cell infiltrationUICC stagingprognosis |
| spellingShingle | Verena Maria Raters Florian Gebauer Heike Löser Wolfgang Schröder Hans Anton Schlösser Hans Fuchs Christiane Bruns Alexander Quaas Thomas Zander Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma Frontiers in Oncology esophageal adenocarcinoma Y chromosome loss CD3 cell infiltration UICC staging prognosis |
| title | Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma |
| title_full | Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma |
| title_fullStr | Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma |
| title_full_unstemmed | Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma |
| title_short | Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma |
| title_sort | combined score of y chromosome loss and t cell infiltration improves uicc based stratification of esophageal adenocarcinoma |
| topic | esophageal adenocarcinoma Y chromosome loss CD3 cell infiltration UICC staging prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1249172/full |
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