Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies
Hepatic encephalopathy (HE) is a potentially reversible neuropsychiatric syndrome. Often, HE causes cognitive and motor dysfunctions due to an acute or chronic insufficiency of the liver or a shunting between the hepatic portal vein and systemic vasculature. Liver damage induces peripheral changes,...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2023-07-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1767819 |
| _version_ | 1797771565753958400 |
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| author | Rafaela Pinto Coelho Santos Eliana Cristina de Brito Toscano Milene Alvarenga Rachid |
| author_facet | Rafaela Pinto Coelho Santos Eliana Cristina de Brito Toscano Milene Alvarenga Rachid |
| author_sort | Rafaela Pinto Coelho Santos |
| collection | DOAJ |
| description | Hepatic encephalopathy (HE) is a potentially reversible neuropsychiatric syndrome. Often, HE causes cognitive and motor dysfunctions due to an acute or chronic insufficiency of the liver or a shunting between the hepatic portal vein and systemic vasculature. Liver damage induces peripheral changes, such as in the metabolism and peripheral inflammatory responses that trigger exacerbated neuroinflammation. In experimental models, anti-inflammatory strategies have demonstrated neuroprotective effects, leading to a reduction in HE-related cognitive and motor impairments. In this scenario, a growing body of evidence has shown that peripheral and central nervous system inflammation are promising preclinical targets. In this review, we performed an overview of FDA-approved drugs and natural compounds which are used in the treatment of other neurological and nonneurological diseases that have played a neuroprotective role in experimental HE, at least in part, through anti-inflammatory mechanisms. Despite the exciting results from animal models, the available data should be critically interpreted, highlighting the importance of translating the findings for clinical essays. |
| first_indexed | 2024-03-12T21:39:26Z |
| format | Article |
| id | doaj.art-5d743dc9314d4da892de70f5121058b3 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-03-12T21:39:26Z |
| publishDate | 2023-07-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-5d743dc9314d4da892de70f5121058b32023-07-27T05:50:55ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-07-01810765666910.1055/s-0043-1767819Anti-inflammatory strategies for hepatic encephalopathy: preclinical studiesRafaela Pinto Coelho Santos0https://orcid.org/0000-0002-4976-5931Eliana Cristina de Brito Toscano1https://orcid.org/0000-0002-8756-0689Milene Alvarenga Rachid2https://orcid.org/0000-0002-3142-6552Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Laboratório de Patologia Celular e Molecular, Belo Horizonte MG, Brazil.Universidade Federal de Juiz de Fora, Faculdade de Medicina, Departamento de Patologia, Laboratório Integrado de Pesquisa em Patologia, Juiz de Fora MG, Brazil.Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Patologia Geral, Laboratório de Patologia Celular e Molecular, Belo Horizonte MG, Brazil.Hepatic encephalopathy (HE) is a potentially reversible neuropsychiatric syndrome. Often, HE causes cognitive and motor dysfunctions due to an acute or chronic insufficiency of the liver or a shunting between the hepatic portal vein and systemic vasculature. Liver damage induces peripheral changes, such as in the metabolism and peripheral inflammatory responses that trigger exacerbated neuroinflammation. In experimental models, anti-inflammatory strategies have demonstrated neuroprotective effects, leading to a reduction in HE-related cognitive and motor impairments. In this scenario, a growing body of evidence has shown that peripheral and central nervous system inflammation are promising preclinical targets. In this review, we performed an overview of FDA-approved drugs and natural compounds which are used in the treatment of other neurological and nonneurological diseases that have played a neuroprotective role in experimental HE, at least in part, through anti-inflammatory mechanisms. Despite the exciting results from animal models, the available data should be critically interpreted, highlighting the importance of translating the findings for clinical essays.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1767819Hepatic EncephalopathyNeuroinflammatory DiseasesNeuroprotectionModels, AnimalEncefalopatia HepáticaDoenças NeuroinflamatóriasNeuroproteçãoModelos Animais |
| spellingShingle | Rafaela Pinto Coelho Santos Eliana Cristina de Brito Toscano Milene Alvarenga Rachid Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies Arquivos de Neuro-Psiquiatria Hepatic Encephalopathy Neuroinflammatory Diseases Neuroprotection Models, Animal Encefalopatia Hepática Doenças Neuroinflamatórias Neuroproteção Modelos Animais |
| title | Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies |
| title_full | Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies |
| title_fullStr | Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies |
| title_full_unstemmed | Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies |
| title_short | Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies |
| title_sort | anti inflammatory strategies for hepatic encephalopathy preclinical studies |
| topic | Hepatic Encephalopathy Neuroinflammatory Diseases Neuroprotection Models, Animal Encefalopatia Hepática Doenças Neuroinflamatórias Neuroproteção Modelos Animais |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1767819 |
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