Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes
Today, the production and use of various samples of recombinant protein/polypeptide toxins is known and is actively developing. This review presents state-of-the-art in research and development of such toxins and their mechanisms of action and useful properties that have allowed them to be implement...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/5/4630 |
| _version_ | 1797615160057135104 |
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| author | Elena Efremenko Aysel Aslanli Ilya Lyagin |
| author_facet | Elena Efremenko Aysel Aslanli Ilya Lyagin |
| author_sort | Elena Efremenko |
| collection | DOAJ |
| description | Today, the production and use of various samples of recombinant protein/polypeptide toxins is known and is actively developing. This review presents state-of-the-art in research and development of such toxins and their mechanisms of action and useful properties that have allowed them to be implemented into practice to treat various medical conditions (including oncology and chronic inflammation applications) and diseases, as well as to identify novel compounds and to detoxify them by diverse approaches (including enzyme antidotes). Special attention is given to the problems and possibilities of the toxicity control of the obtained recombinant proteins. The recombinant prions are discussed in the frame of their possible detoxification by enzymes. The review discusses the feasibility of obtaining recombinant variants of toxins in the form of protein molecules modified with fluorescent proteins, affine sequences and genetic mutations, allowing us to investigate the mechanisms of toxins’ bindings to their natural receptors. |
| first_indexed | 2024-03-11T07:22:33Z |
| format | Article |
| id | doaj.art-5d75171891d045a4b9715e480b3c1ace |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:33Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5d75171891d045a4b9715e480b3c1ace2023-11-17T07:51:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245463010.3390/ijms24054630Advanced Situation with Recombinant Toxins: Diversity, Production and Application PurposesElena Efremenko0Aysel Aslanli1Ilya Lyagin2Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, Moscow 119991, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, Moscow 119991, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, Moscow 119991, RussiaToday, the production and use of various samples of recombinant protein/polypeptide toxins is known and is actively developing. This review presents state-of-the-art in research and development of such toxins and their mechanisms of action and useful properties that have allowed them to be implemented into practice to treat various medical conditions (including oncology and chronic inflammation applications) and diseases, as well as to identify novel compounds and to detoxify them by diverse approaches (including enzyme antidotes). Special attention is given to the problems and possibilities of the toxicity control of the obtained recombinant proteins. The recombinant prions are discussed in the frame of their possible detoxification by enzymes. The review discusses the feasibility of obtaining recombinant variants of toxins in the form of protein molecules modified with fluorescent proteins, affine sequences and genetic mutations, allowing us to investigate the mechanisms of toxins’ bindings to their natural receptors.https://www.mdpi.com/1422-0067/24/5/4630recombinant toxinproteinexotoxinkiller toxinprionantivenom |
| spellingShingle | Elena Efremenko Aysel Aslanli Ilya Lyagin Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes International Journal of Molecular Sciences recombinant toxin protein exotoxin killer toxin prion antivenom |
| title | Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes |
| title_full | Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes |
| title_fullStr | Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes |
| title_full_unstemmed | Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes |
| title_short | Advanced Situation with Recombinant Toxins: Diversity, Production and Application Purposes |
| title_sort | advanced situation with recombinant toxins diversity production and application purposes |
| topic | recombinant toxin protein exotoxin killer toxin prion antivenom |
| url | https://www.mdpi.com/1422-0067/24/5/4630 |
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