New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing
New hydrogels nanocomposites, based on iminoboronate hydrogels and ZnO nanoparticles (ZnO–NPs), were obtained and characterised in order to develop a new class of disinfectants able to fight the nosocomial infections produced by duodenoscopes investigation procedures. The formation of the imine link...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/12/2669 |
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| author | Daniela Ailincai Ioana-Andreea Turin Moleavin Alexandra Sarghi Adrian Fifere Oana Dumbrava Mariana Pinteala Gheorghe G. Balan Irina Rosca |
| author_facet | Daniela Ailincai Ioana-Andreea Turin Moleavin Alexandra Sarghi Adrian Fifere Oana Dumbrava Mariana Pinteala Gheorghe G. Balan Irina Rosca |
| author_sort | Daniela Ailincai |
| collection | DOAJ |
| description | New hydrogels nanocomposites, based on iminoboronate hydrogels and ZnO nanoparticles (ZnO–NPs), were obtained and characterised in order to develop a new class of disinfectants able to fight the nosocomial infections produced by duodenoscopes investigation procedures. The formation of the imine linkages between chitosan and the aldehyde was demonstrated using NMR and FTIR spectroscopy, while the supramolecular architecture of the developed systems was evaluated via wide-angle X-ray diffraction and polarised optical microscopy. The morphological characterisation of the systems via scanning electron microscopy revealed the highly porous structure of the materials, in which no ZnO agglomeration could be observed, indicating the very fine and homogenous encapsulation of the nanoparticles into the hydrogels. The newly synthetised hydrogels nanocomposites was proven to have synergistic antimicrobial properties, being very efficient as disinfectants against reference strains as: <i>Enterococcus faecalis</i>, <i>Klebsiella pneumoniae</i>, and <i>Candida albicans</i>. |
| first_indexed | 2024-03-11T02:00:58Z |
| format | Article |
| id | doaj.art-5d75c18a184d4b2584d9fdaeb3cf76c5 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T02:00:58Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5d75c18a184d4b2584d9fdaeb3cf76c52023-11-18T12:13:03ZengMDPI AGPolymers2073-43602023-06-011512266910.3390/polym15122669New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes ReprocessingDaniela Ailincai0Ioana-Andreea Turin Moleavin1Alexandra Sarghi2Adrian Fifere3Oana Dumbrava4Mariana Pinteala5Gheorghe G. Balan6Irina Rosca7“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaFaculty of Medicine, ‘Grigore T. Popa’ University of Medicine, 700115 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaNew hydrogels nanocomposites, based on iminoboronate hydrogels and ZnO nanoparticles (ZnO–NPs), were obtained and characterised in order to develop a new class of disinfectants able to fight the nosocomial infections produced by duodenoscopes investigation procedures. The formation of the imine linkages between chitosan and the aldehyde was demonstrated using NMR and FTIR spectroscopy, while the supramolecular architecture of the developed systems was evaluated via wide-angle X-ray diffraction and polarised optical microscopy. The morphological characterisation of the systems via scanning electron microscopy revealed the highly porous structure of the materials, in which no ZnO agglomeration could be observed, indicating the very fine and homogenous encapsulation of the nanoparticles into the hydrogels. The newly synthetised hydrogels nanocomposites was proven to have synergistic antimicrobial properties, being very efficient as disinfectants against reference strains as: <i>Enterococcus faecalis</i>, <i>Klebsiella pneumoniae</i>, and <i>Candida albicans</i>.https://www.mdpi.com/2073-4360/15/12/2669chitosan hydrogelsboronic aldehydeZnOdisinfectant |
| spellingShingle | Daniela Ailincai Ioana-Andreea Turin Moleavin Alexandra Sarghi Adrian Fifere Oana Dumbrava Mariana Pinteala Gheorghe G. Balan Irina Rosca New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing Polymers chitosan hydrogels boronic aldehyde ZnO disinfectant |
| title | New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing |
| title_full | New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing |
| title_fullStr | New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing |
| title_full_unstemmed | New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing |
| title_short | New Hydrogels Nanocomposites Based on Chitosan, 2-Formylphenylboronic Acid, and ZnO Nanoparticles as Promising Disinfectants for Duodenoscopes Reprocessing |
| title_sort | new hydrogels nanocomposites based on chitosan 2 formylphenylboronic acid and zno nanoparticles as promising disinfectants for duodenoscopes reprocessing |
| topic | chitosan hydrogels boronic aldehyde ZnO disinfectant |
| url | https://www.mdpi.com/2073-4360/15/12/2669 |
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