Hyper-Branched Cationic Cyclodextrin Polymers for Improving Plasmid Transfection in 2D and 3D Spheroid Cells

Hyper-Branched Cationic Cyclodextrin Polymers for Improving Plasmid Transfection in 2D and 3D Spheroid Cells

In this article, we used monolayer two dimensional (2D) and 3D multicellular spheroid models to improve our understanding of the gene delivery process of a new modified cationic hyper-branched cyclodextrin-based polymer (Ppoly)-loaded plasmid encoding Enhanced Green Fluorescent Protein (EGFP). A com...

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Bibliographic Details
Main Authors: Yousef Khazaei Monfared, Mohammad Mahmoudian, Claudio Cecone, Fabrizio Caldera, Sanya Haiaty, Hamid Reza Heidari, Reza Rahbarghazi, Adrián Matencio, Parvin Zakeri-Milani, Francesco Trotta
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
cyclodextrin hyperbranched polymers
transfection
plasmid eGFP
spheroid 3D
DAPI
Online Access:https://www.mdpi.com/1999-4923/14/12/2690

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