<i>Cis</i>-Acting Factors Causing Secondary Epimutations: Impact on the Risk for Cancer and Other Diseases

<i>Cis</i>-Acting Factors Causing Secondary Epimutations: Impact on the Risk for Cancer and Other Diseases

Epigenetics affects gene expression and contributes to disease development by alterations known as epimutations. Hypermethylation that results in transcriptional silencing of tumor suppressor genes has been described in patients with hereditary cancers and without pathogenic variants in the coding r...

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Main Authors: Miguel Ruiz de la Cruz, Aldo Hugo de la Cruz Montoya, Ernesto Arturo Rojas Jiménez, Héctor Martínez Gregorio, Clara Estela Díaz Velásquez, Jimena Paredes de la Vega, Fidel de la Cruz Hernández-Hernández, Felipe Vaca Paniagua
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
epigenetic
epimutations
promoter hypermethylation
secondary epimutations
<i>cis</i>-acting factors
Online Access:https://www.mdpi.com/2072-6694/13/19/4807

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