Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice
Summary: Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family of cytokines, is produced by inflammatory fibroblasts during acute colitis....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223000111 |
| _version_ | 1797903377426808832 |
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| author | Takashi Nishina Yutaka Deguchi Mika Kawauchi Chen Xiyu Soh Yamazaki Tetuo Mikami Hiroyasu Nakano |
| author_facet | Takashi Nishina Yutaka Deguchi Mika Kawauchi Chen Xiyu Soh Yamazaki Tetuo Mikami Hiroyasu Nakano |
| author_sort | Takashi Nishina |
| collection | DOAJ |
| description | Summary: Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family of cytokines, is produced by inflammatory fibroblasts during acute colitis. However, the role of IL-11 in the development of colitis is still unclear. Herein, we showed that IL-11 ameliorated DSS-induced acute colitis in mouse models. We found that deletion of Il11ra1 or Il11 rendered mice highly susceptible to DSS-induced colitis compared to the respective control mice. The number of apoptotic epithelial cells was increased in DSS-treated Il11ra1- or Il11-deficient mice. Moreover, we showed that IL-11 production was regulated by reactive oxygen species (ROS) produced by lysozyme M-positive myeloid cells. These findings indicate that fibroblast-produced IL-11 plays an important role in protecting the mucosal epithelium in acute colitis. Myeloid cell-derived ROS contribute to the attenuation of colitis through the production of IL-11. |
| first_indexed | 2024-04-10T09:31:56Z |
| format | Article |
| id | doaj.art-5d790513113647d692f975e0b346bfa2 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T09:31:56Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-5d790513113647d692f975e0b346bfa22023-02-19T04:26:36ZengElsevieriScience2589-00422023-02-01262105934Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in miceTakashi Nishina0Yutaka Deguchi1Mika Kawauchi2Chen Xiyu3Soh Yamazaki4Tetuo Mikami5Hiroyasu Nakano6Department of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan; Corresponding authorDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan; Tokyo College of Biotechnology, 1-3-14 Kitakoujiya, Ota-ku, Tokyo 144-0032, JapanDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Pathology, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, JapanDepartment of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan; Host Defense Research Center, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan; Corresponding authorSummary: Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family of cytokines, is produced by inflammatory fibroblasts during acute colitis. However, the role of IL-11 in the development of colitis is still unclear. Herein, we showed that IL-11 ameliorated DSS-induced acute colitis in mouse models. We found that deletion of Il11ra1 or Il11 rendered mice highly susceptible to DSS-induced colitis compared to the respective control mice. The number of apoptotic epithelial cells was increased in DSS-treated Il11ra1- or Il11-deficient mice. Moreover, we showed that IL-11 production was regulated by reactive oxygen species (ROS) produced by lysozyme M-positive myeloid cells. These findings indicate that fibroblast-produced IL-11 plays an important role in protecting the mucosal epithelium in acute colitis. Myeloid cell-derived ROS contribute to the attenuation of colitis through the production of IL-11.http://www.sciencedirect.com/science/article/pii/S2589004223000111Components of the immune systemImmunologyMolecular physiology |
| spellingShingle | Takashi Nishina Yutaka Deguchi Mika Kawauchi Chen Xiyu Soh Yamazaki Tetuo Mikami Hiroyasu Nakano Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice iScience Components of the immune system Immunology Molecular physiology |
| title | Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice |
| title_full | Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice |
| title_fullStr | Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice |
| title_full_unstemmed | Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice |
| title_short | Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice |
| title_sort | interleukin 11 confers resistance to dextran sulfate sodium induced colitis in mice |
| topic | Components of the immune system Immunology Molecular physiology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223000111 |
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