Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine
Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more acti...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/1/20 |
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| author | Noelia González-Ballesteros Immacolata Maietta Raquel Rey-Méndez M. Carmen Rodríguez-Argüelles Mariano Lastra-Valdor Antonella Cavazza Maria Grimaldi Franca Bigi Rosana Simón-Vázquez |
| author_facet | Noelia González-Ballesteros Immacolata Maietta Raquel Rey-Méndez M. Carmen Rodríguez-Argüelles Mariano Lastra-Valdor Antonella Cavazza Maria Grimaldi Franca Bigi Rosana Simón-Vázquez |
| author_sort | Noelia González-Ballesteros |
| collection | DOAJ |
| description | Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more active antitumoral agents. Furthermore, these natural extracts can be combined with nanotechnology to increase their efficacy and improve targeting. In this work, a <i>Codium tomentosum</i> (CT) aqueous extract was employed for the green synthesis of gold nanoparticles (Au@CT). The complete characterization of Au@CT was performed by UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Zeta potential, electron microscopy, X-ray powder diffraction (XRD), high-performance steric exclusion chromatography (HPSEC), and by the determination of their antioxidant capacity. The antiproliferative activity of Au@CT was then tested in hepatic (HEPG-2) and pancreatic (BxPC-3) cell lines. Their potential capacity as enhancers of gemcitabine, a drug frequently used to treat both types of tumors, was also tested. The activity of Au@CT was compared to the activity of the CT extract alone. A synergistic effect with gemcitabine was proven for HEPG-2. Our results showed that gold nanoparticles synthesized from seaweed extracts with antitumoral activity could be a good gemcitabine enhancer. |
| first_indexed | 2024-03-09T11:52:24Z |
| format | Article |
| id | doaj.art-5d799ad110314e53bde0ebf868d52d80 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T11:52:24Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-5d799ad110314e53bde0ebf868d52d802023-11-30T23:13:23ZengMDPI AGMarine Drugs1660-33972022-12-012112010.3390/md21010020Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of GemcitabineNoelia González-Ballesteros0Immacolata Maietta1Raquel Rey-Méndez2M. Carmen Rodríguez-Argüelles3Mariano Lastra-Valdor4Antonella Cavazza5Maria Grimaldi6Franca Bigi7Rosana Simón-Vázquez8CINBIO, Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, SpainCINBIO, Inmunology Group, Universidade de Vigo, 36310 Vigo, SpainCINBIO, Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, SpainCINBIO, Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, SpainCentro de Investigación Marina, Universidade de Vigo, 36331 Vigo, SpainDipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, ItalyDipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, ItalyDipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, ItalyCINBIO, Inmunology Group, Universidade de Vigo, 36310 Vigo, SpainCancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more active antitumoral agents. Furthermore, these natural extracts can be combined with nanotechnology to increase their efficacy and improve targeting. In this work, a <i>Codium tomentosum</i> (CT) aqueous extract was employed for the green synthesis of gold nanoparticles (Au@CT). The complete characterization of Au@CT was performed by UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Zeta potential, electron microscopy, X-ray powder diffraction (XRD), high-performance steric exclusion chromatography (HPSEC), and by the determination of their antioxidant capacity. The antiproliferative activity of Au@CT was then tested in hepatic (HEPG-2) and pancreatic (BxPC-3) cell lines. Their potential capacity as enhancers of gemcitabine, a drug frequently used to treat both types of tumors, was also tested. The activity of Au@CT was compared to the activity of the CT extract alone. A synergistic effect with gemcitabine was proven for HEPG-2. Our results showed that gold nanoparticles synthesized from seaweed extracts with antitumoral activity could be a good gemcitabine enhancer.https://www.mdpi.com/1660-3397/21/1/20<i>Codium tomentosum</i>gold nanoparticlesgreen synthesisantitumoralgemcitabine enhancerHEPG-2 |
| spellingShingle | Noelia González-Ballesteros Immacolata Maietta Raquel Rey-Méndez M. Carmen Rodríguez-Argüelles Mariano Lastra-Valdor Antonella Cavazza Maria Grimaldi Franca Bigi Rosana Simón-Vázquez Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine Marine Drugs <i>Codium tomentosum</i> gold nanoparticles green synthesis antitumoral gemcitabine enhancer HEPG-2 |
| title | Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine |
| title_full | Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine |
| title_fullStr | Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine |
| title_full_unstemmed | Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine |
| title_short | Gold Nanoparticles Synthesized by an Aqueous Extract of <i>Codium tomentosum</i> as Potential Antitumoral Enhancers of Gemcitabine |
| title_sort | gold nanoparticles synthesized by an aqueous extract of i codium tomentosum i as potential antitumoral enhancers of gemcitabine |
| topic | <i>Codium tomentosum</i> gold nanoparticles green synthesis antitumoral gemcitabine enhancer HEPG-2 |
| url | https://www.mdpi.com/1660-3397/21/1/20 |
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